{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:55:10Z","timestamp":1777398910263,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1984,7,1]],"date-time":"1984-07-01T00:00:00Z","timestamp":457488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1984,7]]},"abstract":"<jats:p>\n                    The red blood cell flexibility was studied in the blood of twenty patients with severe peripheral vascular disease and twenty matched controls. Patients exhibited significantly less red cell flexibility than controls. In both groups there was an inverse relationship between age and red cell flexibility. No correlation was found between red cell flexibility and sex or smoking history. Pentoxifylline, a xanthine derivative which inhibits phosphodiesterases and platelet aggregation, was found to increase red cell flexibility. This effect of the drug was greater on red cells with impaired flexibility than on normal cells. Various prostaglandins by contrast were found to decrease red cell flexibility, this could be compensated for by pentoxifylline. Forty patients with COAD were treated intravenously with PgE\n                    <jats:sub>1<\/jats:sub>\n                    . Significant inhibition of platelet aggregation and clinical improvement was noticed. It is suggested that combinations of PgE\n                    <jats:sub>1<\/jats:sub>\n                    and pentoxifylline should be explored in clinical studies.\n                  <\/jats:p>","DOI":"10.1177\/000331978403500704","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"418-426","source":"Crossref","is-referenced-by-count":17,"title":["Red Cell Flexibility and Platelet Aggregation in Patients with Chronic Obstructive Vascular Disease (COAD) and Study of Therapeutic Approaches"],"prefix":"10.1177","volume":"35","author":[{"given":"J.L.","family":"Ambrus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Ambrus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Gastpar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Reddington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.L.","family":"Schattman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.S.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.H.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5892.576"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5892.581"},{"key":"atypb3","first-page":"319","volume":"5","author":"Ehrly AM","year":"1976","journal-title":"VASA"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.29.9.855"},{"key":"atypb5","first-page":"106","volume":"42","author":"Drummond MM","year":"1979","journal-title":"Thromb Haemostas"},{"key":"atypb6","first-page":"348","volume":"42","author":"Stuart J.","year":"1979","journal-title":"Thromb Haemostas"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/000331977702800705"},{"key":"atypb8","first-page":"51","volume":"15","author":"Knight K.","year":"1978","journal-title":"Biorheology"},{"issue":"2","key":"atypb9","first-page":"897","volume":"25","author":"Schmid-Schonbein H.","year":"1976","journal-title":"Diabetes"},{"key":"atypb10","first-page":"530","volume":"56","author":"Circette B.","year":"1978","journal-title":"Ann Biol Clin"},{"key":"atypb11","first-page":"331","volume":"10","author":"Ehrly AM","year":"1979","journal-title":"J Med"},{"key":"atypb12","first-page":"307","volume":"10","author":"Muller R.","year":"1979","journal-title":"J Med"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90642-1"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1972.03200200011003"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2340\/0001555560425430","volume":"60","author":"Beitner H.","year":"1980","journal-title":"Acta Derm Venereol"},{"key":"atypb16","first-page":"826","volume":"88","author":"Pardy BJ","year":"1980","journal-title":"Surgery"},{"key":"atypb17","author":"Ambrus JL","year":"1983","journal-title":"J Med"},{"key":"atypb18","author":"Taheri SA","year":"1983","journal-title":"Angiology"},{"key":"atypb19","unstructured":"Ambrus JL, Ambrus CM, Gastpar H.: Studies on platelet aggregation and on platelet interaction with tumor cells . In: Platelets: A Multidisciplinary Approach, ed. by de Gaetano G and Garattini S. New York, Raven Press, 1978, pp. 467."},{"key":"atypb20","unstructured":"Ambrus JL, Ambrus CM: Anticoagulants, fibrinolytic enzymes and platelet aggregation inhibitors in cancer chemotherapy. In: Cancer Chemotherapy III. The Forty-Sixth Hahnemann Symposium, ed. by Brodsky I, Kahn SB, Conroy JF. New York, Grune and Stratton, 1978 , pp. 97-109."},{"key":"atypb21","first-page":"924","volume":"2","author":"Wu KK","year":"1974","journal-title":"Lancet"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(75)90095-X"},{"key":"atypb23","unstructured":"Ambrus JL, Ambrus CM: Blood coagulation in neoplastic disease. In: Onkohamostaseologie (Hematologic Problems in Cancer), ed. by Gastpar H. Stuttgart-New York , F. K. 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