{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:55:25Z","timestamp":1777398925678,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1985,1,1]],"date-time":"1985-01-01T00:00:00Z","timestamp":473385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:p>Infusions of hydroxyethylstarch (HES) solutions as plasma substitutes and flow improvers play an increasing role in the treatment of various diseases. Little is known about the effect of HES solutions of different molecular weights on the flow properties of blood i. e. blood viscosity, plasma viscosity, erythrocyte aggregation and erythrocyte deformability (filtrability). In the present study the influence of 500 ml-infusions of a 6% solution of HES (MW 450,000) has been compared to that of 6% solutions of HES 40,000.<\/jats:p>\n                  <jats:p>Infusions of 500 ml of HES 450,000 into healthy persons induced a hemodilution with a subsequent decrease in whole blood viscosity whereas the plasma viscosity increased. Red cell aggregation increased as well, red cell deformability was slightly impaired.<\/jats:p>\n                  <jats:p>Infusions of 500 ml of HES 40,000 into healthy persons were followed by a hemodilution with a decrease in blood and plasma viscosity, a decrease in erythrocyte aggregation and a slight improvement of red cell deformability. The reason for this difference in behaviour and its therapeutical consequences are discussed.<\/jats:p>","DOI":"10.1177\/000331978503600107","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"41-44","source":"Crossref","is-referenced-by-count":5,"title":["Influence of Intravenous Infusions of Hydroxyethylstarch (HES) (MW 40,000 and 450,000) on the Blood Flow Properties of Healthy Volunteers"],"prefix":"10.1177","volume":"36","author":[{"given":"Albrecht M.","family":"Ehrly","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Angiology, Johann-Wolfgang-Goethe-University, Frankfurt\/Main, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Landgraf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Angiology, Johann-Wolfgang-Goethe-University, Frankfurt\/Main, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,1,1]]},"reference":[{"key":"atypb1","first-page":"289","volume":"126","author":"Bergentz S.","year":"1965","journal-title":"Acta chir scand"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196605000-00007"},{"key":"atypb3","first-page":"456","volume":"57","author":"Bollinger A.","year":"1968","journal-title":"Z. Kreislaufforschung"},{"key":"atypb4","first-page":"9","volume":"148","author":"Burke AM","year":"1979","journal-title":"Gynec Obstet"},{"key":"atypb5","first-page":"989","volume":"61","author":"Ehrly AM","year":"1966","journal-title":"Med Klin"},{"key":"atypb6","first-page":"331","volume":"6","author":"Ehrly AM","year":"1979","journal-title":"Infusionstherapie"},{"key":"atypb7","unstructured":"Landgraf H. and Ehrly AM: Effects of an infusion of low molecular weight hydroxyethylstarch (HES) on the rheological properties of blood from healthy volunteers. In: Hemorheolgy and Diseases. Ed. by Stoltz and Drouin. Doin, Paris, 1980, pp. 677-681."},{"key":"atypb8","volume-title":"Untertsuchungen \u00fcber den Einflu\u00df von Hydroxy\u00e4thylst\u00e4rke auf die Flie\u00dfeigenschaften des Blutes","author":"Keppeler D.","year":"1977"},{"key":"atypb9","volume-title":"Entwicklung und Darstellung einer Methode zur Messung der Erythrozytenaggregation","author":"Ehrly AM"},{"key":"atypb10","unstructured":"Ehrly AM and Ro\u00dfbach P.: The detection of changes in erythrocyte shape by a filtration method using 8 \u03bcmfilters. In: Erythrocytes, Thrombocytes, Leukocytes . Ed. by Gerlach E, Moser K, Deutsch E, Wilmans W. Thieme, Stuttgart, 1973, p. 52."},{"key":"atypb11","first-page":"55","volume":"11","author":"Ehrly AM","year":"1973","journal-title":"Bibl anat"},{"key":"atypb12","unstructured":"Ehrly AM, Landgraf H., Saeger-Lorenz K.: Quantification of the effects of rheological active drugs in patients with vascular dieases. In: Hemorheology and Diseases. Ed. by Stoltz an Drouin, Doin, Paris, 1980, pp. 665-667."},{"key":"atypb13","first-page":"302","volume":"33","author":"Ehrly AM","year":"1969","journal-title":"Bibl haemat"},{"key":"atypb14","first-page":"275","volume":"11","author":"Ehrly AM","year":"1979","journal-title":"Herz\/Kreislauf"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978503600107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978503600107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:14:05Z","timestamp":1777371245000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978503600107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1177\/000331978503600107"],"URL":"https:\/\/doi.org\/10.1177\/000331978503600107","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}