{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:58:36Z","timestamp":1777399116210,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1985,7,1]],"date-time":"1985-07-01T00:00:00Z","timestamp":489024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:p>\n                    In 42 patients with arterial occlusive disease of the leg, the hemodynamic effects of prostaglandin E\n                    <jats:sub>1<\/jats:sub>\n                    (PGE\n                    <jats:sub>1<\/jats:sub>\n                    ) given intravenously were studied. Blood pres sure of the leg and crest time of the pulse wave did not change significantly, while increases in blood flow at the calf and foot, amplitude of the pulse wave, velocity, and skin temperature at the foot and toes were significant. Skin tem perature of the calf dropped significantly. The increase in blood flow, velocity, and skin temperature was significantly more dominant in the distal part of the leg than that in the proximal part. In separate observation of individuals, 12 of the 66 legs with arterial occlusive disease (18%) showed a decrease in skin tem perature at the toes. The steal phenomenon was observed most frequently in limbs with rest pain, gangrene, or both.\n                  <\/jats:p>","DOI":"10.1177\/000331978503600701","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"407-413","source":"Crossref","is-referenced-by-count":13,"title":["Hemodynamic Effects of Intravenous PGE1 on Patients with Arterial Occlusive Disease of the Leg"],"prefix":"10.1177","volume":"36","author":[{"given":"Masafumi","family":"Hirai","sequence":"first","affiliation":[{"name":"Peripheral Vascular Division, the Department of Internal Medicine, Cardiovascular Center Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Nanki","sequence":"additional","affiliation":[{"name":"Peripheral Vascular Division, the Department of Internal Medicine, Cardiovascular Center Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryu","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Peripheral Vascular Division, the Department of Internal Medicine, Cardiovascular Center Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)90233-X"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)90653-X"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1971.220.2.392"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.281.6247.1031"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(81)90163-3"},{"key":"atypb6","first-page":"839","volume":"93","author":"Rhodes RS","year":"1983","journal-title":"Surgery"},{"key":"atypb7","first-page":"447","volume":"33","author":"Barbalinardo JP","year":"1982","journal-title":"Surg Form"},{"key":"atypb8","first-page":"840","volume":"84","author":"Fronek A.","year":"1978","journal-title":"Surgery"},{"key":"atypb9","first-page":"348","volume":"84","author":"Sumner DS","year":"1978","journal-title":"Surgery"},{"key":"atypb10","first-page":"263","volume":"7","author":"Sakaguchi S.","year":"1978","journal-title":"VASA"},{"key":"atypb11","first-page":"215","volume":"6","author":"Hirai M.","year":"1977","journal-title":"VASA"},{"key":"atypb12","unstructured":"Johnston KW: Doppler signal processing and wave form analysis: problems and solutions. In: Noninvasive diagnostic techniques in vascular disease. Ed. by Bernstein EF. St Louis , The CV Mosby Company, 1982, p. 28."},{"key":"atypb13","unstructured":"Sumner DS: Volume plethysmography in vascular disease: an overview. In: Noninvasive diagnostic techniques in vascular disease. Ed. by Bernstein EF. St Louis, The CV Mosby Company, 1982, p. 67."},{"key":"atypb14","first-page":"379","volume":"12","author":"Winsor T.","year":"1971","journal-title":"J Cardiovasc Surg"},{"key":"atypb15","unstructured":"Hill AB: Principles of medical statistics. 9th ed. London, The Lancet Ltd, 1971, p. 143."},{"key":"atypb16","unstructured":"Strandness DE : Peripheral arterial disease. A physiologic approach. Boston, Little Brown and Company, 1969, p. 210."},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/7.5.577"},{"key":"atypb18","first-page":"71","volume":"37","author":"Hirai M.","year":"1975","journal-title":"Nagoya J Med Sci"},{"key":"atypb19","first-page":"467","volume":"58","author":"Olsson AG","year":"1978","journal-title":"Acta Dermatovener"},{"key":"atypb20","first-page":"1","volume":"556","author":"Hansteen V.","year":"1974","journal-title":"Acta Med Scand Supp"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978503600701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978503600701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:14:20Z","timestamp":1777371260000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978503600701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1985,7]]}},"alternative-id":["10.1177\/000331978503600701"],"URL":"https:\/\/doi.org\/10.1177\/000331978503600701","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,7]]}}}