{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:02:52Z","timestamp":1777399372473,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[1986,8,1]],"date-time":"1986-08-01T00:00:00Z","timestamp":523238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:p>Reduced activity of serum \u03b2-glucuronidase (EC 3.2.1.31) was found in three patients with Marfan syndrome, two of whom were siblings. The serum \u03b2-glu curonidase levels in the patients ranged from 294 to 439 \u03bcg (360.7\u00b173.2, mean\u00b1SD) of the released P-nitrophenol\/100 ml of serum\/hour, whereas those of 7 healthy subjects ranged from 564 to 1445 \u03bcg (836.4\u00b1287.3). This difference was statistically significant (p &lt; 0.01).<\/jats:p>\n                  <jats:p>Plasma glycosaminoglycan levels in the patients were lower than those in the healthy subjects, owing mainly to the differences in plasma high-sulfated glyco saminoglycan. The correlation coefficients of serum \u03b2-glucuronidase activity with high-sulfated and total plasma glycosaminoglycans were 0.794 and 0.809, respectively (p&lt;0.01 and p &lt; 0.005, respectively).<\/jats:p>\n                  <jats:p>The results suggest that the decreased plasma high-sulfated glycosaminogly can levels in Marfan syndrome are due to the reduction of serum \u03b2-glucuroni dase, which leads to the decreased degradation of macromolecules and, subsequently, the accumulation of the glycosaminoglycans in the tissues.<\/jats:p>","DOI":"10.1177\/000331978603700804","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"576-580","source":"Crossref","is-referenced-by-count":3,"title":["Reduced Activity of Serum \u03b2-Glucuronidase in Marfan Syndrome"],"prefix":"10.1177","volume":"37","author":[{"given":"Yasuhide","family":"Nakashima","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,8,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1959.00270010129017"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(58)90480-X"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80531-6"},{"key":"atypb4","first-page":"45","volume":"8","author":"Hurley JV","year":"1959","journal-title":"Aust Ann Med"},{"key":"atypb5","first-page":"1087","volume":"12","author":"Bolande RP","year":"1963","journal-title":"Lab Invest"},{"key":"atypb6","first-page":"635","volume":"44","author":"Manley G.","year":"1963","journal-title":"Exp Pathol"},{"key":"atypb7","first-page":"483","volume":"25","author":"Symbas PN","year":"1970","journal-title":"Surgical treatment and new histochemical observations. Am J Cardiol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1963.03620250062010"},{"key":"atypb9","first-page":"221","volume":"55","author":"Bacchus H.","year":"1960","journal-title":"J Lab Clin Med"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a130742"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105989"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(77)90179-4"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)35155-4"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)86449-9"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12556863"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978603700804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978603700804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:14:56Z","timestamp":1777371296000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978603700804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["10.1177\/000331978603700804"],"URL":"https:\/\/doi.org\/10.1177\/000331978603700804","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}