{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:03:12Z","timestamp":1777399392013,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1986,8,1]],"date-time":"1986-08-01T00:00:00Z","timestamp":523238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:p>Intravenous clonidine was used to treat systolic hypertension (systolic blood pressure greater than 160 mm Hg) in 15 patients with acute myocardial infarction and documented sympathetic overactivity (high plasma norepinephrine). Its effects on haemodynamics and blood gases were studied.<\/jats:p>\n                  <jats:p>\n                    After one hour, clonidine significantly reduced the systolic (195\u00b17 to 137\u00b17 mm Hg, p &lt; 0.01) and diastolic (81\u00b14 to 60\u00b13 mm Hg, p &lt; 0.01) blood pressures as well as the systemic vascular resistance (26\u00b12 to 20\u00b11 IU, p &lt; 0.01). The cardiac index was reduced from 2.8\u00b10.2 to 2.4\u00b10.2 l\/min.m\n                    <jats:sup>2<\/jats:sup>\n                    , p&lt;0.01. This change was related to a reduction of the heart rate (92\u00b14 to 81\u00b14 beats\/ min, p &lt; 0.01) as the stroke index was unchanged. Pulmonary wedge pressure (15\u00b13 to 10\u00b12 mm Hg, p &lt; 0.01) and rate pressure product (18.034\u00b11.159 to 11.274\u00b1917 mm Hg, beats\/min, p &lt; 0.01) were also significantly decreased. The arterial oxygen tension did not change significantly but there was a significant drop in the mixed venous oxygen saturation (63\u00b12 to 61\u00b12%, p&lt;0.02) and oxygen transport (433\u00b141 to 409\u00b136, p &lt; 0.01).\n                  <\/jats:p>\n                  <jats:p>Clonidine is thus able to normalize blood pressure in acute myocardial infarction ; this is accompanied by a reduction in myocardial oxygen requirements and pulmonary wedge pressure. Oxygen transport to the tissues, however, may be decreased.<\/jats:p>","DOI":"10.1177\/000331978603700903","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"633-641","source":"Crossref","is-referenced-by-count":1,"title":["Central Inhibition of Sympathetic Overdrive by Clonidine in Acute Myocardial Infarction with Systolic Hypertension. Haemodynamic Study"],"prefix":"10.1177","volume":"37","author":[{"given":"Marc","family":"Renard","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital Saint-Pierre, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Liebens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Saint-Pierre, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Waterschoot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Saint-Pierre, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Saint-Pierre, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,8,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(78)90158-8"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5976.128"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.72.5.618"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197409052911001"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.33.6.878"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5980.432"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.82.4.404"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.83.2.203"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)81570-4"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.47.1.1"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(79)90278-3"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1979.tb04787.x"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a061141"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198401000-00014"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(84)90353-X"},{"key":"atypb16","first-page":"655","volume":"64","author":"Shepherd JT","year":"1981","journal-title":"N Engl J Med"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(83)80135-0"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(80)90767-X"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978603700903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978603700903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:14:58Z","timestamp":1777371298000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978603700903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["10.1177\/000331978603700903"],"URL":"https:\/\/doi.org\/10.1177\/000331978603700903","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}