{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:03:30Z","timestamp":1777399410837,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1986,8,1]],"date-time":"1986-08-01T00:00:00Z","timestamp":523238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:p>Platelet aggregate size was measured in 178 patients with ischemic heart disease, among whom 56 had stable angina, 42 suffered from unstable angina, and 80 had had uncomplicated acute myocardial infarction. A group of 50 healthy volunteers and 20 hospitalized noncardiac patients served as controls. Venous blood (0.5 cc) was introduced into a solution containing 11.7 mM EDTA and 1.0 g formaldehyde. Platelet aggregate size was determined by microscopic reading as the number of platelets forming aggregates (per 1000 counted platelets) divided by the number of aggregates. Mean aggregate size was found not significantly different in both control groups, as well as in patients with stable angina and acute myocardial infarction (2.21\u00b10.36 platelets, 2.20\u00b10.58 platelets, 2.28\u00b10.19 platelets, 2.76\u00b11.07 platelets, respectively, p=NS). The highest value was found in the unstable angina group: 4.00\u00b11.40 platelets (p &lt; 0.001 vs other studied groups). Platelet aggregate size was found not to be related to sex, age, medication, or coronary risk factors. Unstable angina may thus be a unique entity in ischemic heart disease concerning its platelet behavior, demonstrated in this study by the increased size of peripheral platelet aggregates, which may have pathogenetic, diagnostic, and eventual therapeutic implications.<\/jats:p>","DOI":"10.1177\/000331978603700910","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"676-682","source":"Crossref","is-referenced-by-count":5,"title":["Circulating Platelet Aggregate Size in Ischemic Heart Disease"],"prefix":"10.1177","volume":"37","author":[{"given":"Itzhak","family":"Weinberger","sequence":"first","affiliation":[{"name":"Israel and Ione Massada Center for Heart Diseases and Department of Internal Medicine \"A,\" Beilinson Medical Center, Petah Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Israel and Ione Massada Center for Heart Diseases and Department of Internal Medicine \"A,\" Beilinson Medical Center, Petah Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Rotenberg","sequence":"additional","affiliation":[{"name":"Israel and Ione Massada Center for Heart Diseases and Department of Internal Medicine \"A,\" Beilinson Medical Center, Petah Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Almozlino","sequence":"additional","affiliation":[{"name":"Israel and Ione Massada Center for Heart Diseases and Department of Internal Medicine \"A,\" Beilinson Medical Center, Petah Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Joshua","sequence":"additional","affiliation":[{"name":"Israel and Ione Massada Center for Heart Diseases and Department of Internal Medicine \"A,\" Beilinson Medical Center, Petah Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Agmon","sequence":"additional","affiliation":[{"name":"Israel and Ione Massada Center for Heart Diseases and Department of Internal Medicine \"A,\" Beilinson Medical Center, Petah Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,8,1]]},"reference":[{"key":"atypb1","first-page":"616","volume":"17","author":"Jorgensen L.","year":"1967","journal-title":"Lab Invest"},{"key":"atypb2","first-page":"V13","volume":"62","author":"Harker LA","year":"1980","journal-title":"Circulation"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(79)90002-1"},{"key":"atypb4","first-page":"752","volume":"16","author":"O'Brian JR","year":"1966","journal-title":"Thromb Diath Haemorrh"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5492.888"},{"key":"atypb6","first-page":"812","volume":"32","author":"Salberg N.","year":"1973","journal-title":"Am J Cardiol"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(75)90067-5"},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0002-9149(79)90075-4","volume":"43","author":"Mehta P.","year":"1979","journal-title":"Am J Cardiol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.63.2.300"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90033-2"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(72)90070-6"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb55217.x"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.2.327"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.0954-6820.1980.tb10939.x","volume":"642","author":"Rasi V.","year":"1980","journal-title":"Acta Med Scand"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(81)90665-7"},{"key":"atypb16","doi-asserted-by":"crossref","unstructured":"Cortelloro M. , Boschetti C., Poli EE: B-thromboglobulin and heparin-neutralizing activity in acute myocardial infarction. A controlled response to sulfinpyrazone. Florence International Meeting on Myocardial Infarction. Amsterdam, Excerpta Medica, 1979 , p. 246.","DOI":"10.1055\/s-0039-1687627"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198001243020403"},{"key":"atypb18","first-page":"340","volume":"91","author":"Handin RT","year":"1978","journal-title":"J Lab Clin Med"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1177\/000331977702801006"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.61.1.62"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650047"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a061271"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-3-424"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.59.2.257"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90407-0"},{"key":"atypb26","first-page":"443","volume":"31","author":"Schlezinger MJ","year":"1955","journal-title":"Am J Pathol"},{"key":"atypb27","first-page":"663","volume":"98","author":"Geer JR","year":"1980","journal-title":"Am J Pathol"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978603700910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978603700910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:15:00Z","timestamp":1777371300000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978603700910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["10.1177\/000331978603700910"],"URL":"https:\/\/doi.org\/10.1177\/000331978603700910","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}