{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:59:55Z","timestamp":1777399195932,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[1986,11,1]],"date-time":"1986-11-01T00:00:00Z","timestamp":531187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1986,11]]},"abstract":"\n Eleven patients with hyperadrenergic diabetic postural hypotension and va gal neuropathy were treated in a double-blind, placebo-controlled study with different beta-agonists and antagonists. A single dose of the beta\n 2<\/jats:sub>\n -agonist terbu taline (5 mg) and the beta\n 1<\/jats:sub>\n +\n 2<\/jats:sub>\n -agonist orciprenaline (10 mg) did not reduce the fall in systolic pressure on standing up, despite a significant increase in both supine and standing heart rates. The beta\n 1<\/jats:sub>\n -antagonist with intrinsic sympathi comimetic activity (ISA) acebutolol (200 mg) and the beta\n 1<\/jats:sub>\n -antagonist metopro lol (50 mg) did not influence the fall in systolic pressure either, despite a significant decrease in supine and standing heart rates and disappearance of increase in heart rate on standing up. Only the beta\n 1<\/jats:sub>\n +\n 2<\/jats:sub>\n -antagonist propranolol and the beta\n 1+2<\/jats:sub>\n -antagonist with ISA pindolol (5 mg) could significantly reduce or practically abolish the fall in systolic and diastolic pressure on standing up. This was accompanied by a slight decrease of heart rates and disappearance of difference between supine and standing heart rates, as seen with the other beta- antagonists. Thus, only beta\n 2<\/jats:sub>\n -blockade reduced or abolished the fall in systolic pressure on standing up in our patients. These data were confirmed by a three- week crossover trial in 10 of these patients.\n <\/jats:p>","DOI":"10.1177\/000331978603701110","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"855-862","source":"Crossref","is-referenced-by-count":24,"title":["Effects of Beta Adrenergic Receptor Agonists and Antagonists in Diabetics with Symptoms of Postural Hypotension: A Double-Blind, Placebo-Controlled Study"],"prefix":"10.1177","volume":"37","author":[{"given":"Ton J. M.","family":"Cleophas","sequence":"first","affiliation":[{"name":"Department of Medicine, Merwede Hospital, Sliedrecht-Dordrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans H. W.","family":"Kauw","sequence":"additional","affiliation":[{"name":"Department of Medicine, Merwede Hospital, Sliedrecht-Dordrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cees","family":"Bijl","sequence":"additional","affiliation":[{"name":"Department of Medicine, Merwede Hospital, Sliedrecht-Dordrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Meijers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Merwede Hospital, Sliedrecht-Dordrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Stapper","sequence":"additional","affiliation":[{"name":"Department of Medicine, Merwede Hospital, Sliedrecht-Dordrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6268.929"},{"key":"atypb2","first-page":"324","volume":"90","author":"Chobanian AV","year":"1977","journal-title":"Trans Assoc Am Physicians"},{"key":"atypb3","unstructured":"Plum F.: Orthostatic hypotension. In: Cecil-Loeb Textbook of Medicine , ed. by Beeson PB, McDermott W. Philadelphia, WB Saunders Co., 1979, p. 1928."},{"key":"atypb4","first-page":"383","volume":"28","author":"Wieling W.","year":"1985","journal-title":"Neth J Med"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0024-3205(77)90070-4","volume":"21","author":"Peuler JD","year":"1977","journal-title":"Life Sci"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00283745"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90491-4"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510173131617"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(80)90028-1"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978603701110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978603701110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:14:32Z","timestamp":1777371272000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978603701110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1986,11]]}},"alternative-id":["10.1177\/000331978603701110"],"URL":"https:\/\/doi.org\/10.1177\/000331978603701110","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,11]]}}}