{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:05:08Z","timestamp":1777399508494,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:p>\n                    A polarographic multiwire surface electrode was used for measurement of local oxygen partial pressure (pO\n                    <jats:sub>2<\/jats:sub>\n                    ) on human brain cortex during neurosurgical operations. The two major problems encountered in this application of the electrode involved sterility of the equipment and mounting of the electrode. The described method of sterilization does not alter the electrical properties of the electrode. A special mount was designed to allow free three-dimensional placement of the electrode without exerting pressure on the cortex.\n                  <\/jats:p>\n                  <jats:p>\n                    Basic results of this technique demonstrated that it is possible to distinguish different pO\n                    <jats:sub>2<\/jats:sub>\n                    distribution patterns displayed in pO\n                    <jats:sub>2<\/jats:sub>\n                    histograms for various types of brain tumors and edematous brain tissue. In patients with arteriovenous malformations (AVMs) of the brain, an increase of tissue pO\n                    <jats:sub>2<\/jats:sub>\n                    in cortical areas adjacent to the AVM was the result of extirpation of the lesion.\n                  <\/jats:p>\n                  <jats:p>\n                    The effect of intravenously administered pentoxifylline was studied during extraintracranial bypass operations in patients with cerebrovascular disease. In 7 patients a consistent shift of the pO\n                    <jats:sub>2<\/jats:sub>\n                    histograms to the right, i.e., to higher pO\n                    <jats:sub>2<\/jats:sub>\n                    values, could be demonstrated. Mean pO\n                    <jats:sub>2<\/jats:sub>\n                    values increased statistically significantly by 16\u00b17 mmHg as early as ten minutes after infusion of pentoxifylline. The rapid improvement of tissue oygenation of human brain cortex is thought to be the result of an improvement of microcirculation, for other parameters influencing tissue pO\n                    <jats:sub>2<\/jats:sub>\n                    showed no significant alterations if any.\n                  <\/jats:p>","DOI":"10.1177\/000331978703800303","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"221-225","source":"Crossref","is-referenced-by-count":22,"title":["Tissue pO2 of Human Brain Cortex\u2014Method, Basic Results and Effects of Pentoxifylline"],"prefix":"10.1177","volume":"38","author":[{"given":"Rolf","family":"Schultheiss","sequence":"first","affiliation":[{"name":"Professor and Head; Neurosurgical Clinic, University of Bonn, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Leuwer","sequence":"additional","affiliation":[{"name":"Professor and Head; Neurosurgical Clinic, University of Bonn, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elfriede","family":"Leniger-Follert","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Systemic Physiology, Dortmund, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hansdetlef","family":"Wassmann","sequence":"additional","affiliation":[{"name":"Neurosurgical Clinic, University of Bonn, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"W\u00fcllenweber","sequence":"additional","affiliation":[{"name":"Neurosurgical Clinic, University of Bonn, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581279"},{"key":"atypb2","first-page":"101","author":"Grote J.","year":"1980","journal-title":"Proc Int Conf Nijmegen"},{"key":"atypb3","first-page":"103","volume":"4","author":"Spiegel HU","year":"1981","journal-title":"Med Technik"},{"key":"atypb4","volume-title":"Therapiekontrolle durch \u00dcberwachung des Gewebe-pO2. Eine tierexperimentelle und klinische Studie. Aktuelle Probleme in der Angiologie","author":"Hauss J.","year":"1982"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69360-1_45"},{"key":"atypb6","doi-asserted-by":"crossref","unstructured":"Schultheiss R., et al: Measurement of tissue pO2 on the brain surface: Clinical application of the polarographic method. In: Cerebral Blood Flow and Metabolism Measurement, ed. by Hartmann A, Hoyer S. Berlin , Heidelberg, Springer, 1985, pp. 487-490.","DOI":"10.1007\/978-3-642-70054-5_72"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1159\/000115659"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1185\/03007997709109343"},{"key":"atypb9","first-page":"82","volume":"291","author":"Kessler M.","year":"1966","journal-title":"Pfl\u00fcgers Arch"},{"key":"atypb10","first-page":"112","volume":"3","author":"L\u00fcbbers DW","year":"1969","journal-title":"Resp Res"},{"key":"atypb11","first-page":"743","volume":"91","author":"Hess H.","year":"1973","journal-title":"Fortschr Med"},{"key":"atypb12","first-page":"2300","volume":"26","author":"Ehrly AM","year":"1975","journal-title":"Med Welt"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1159\/000115657"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978703800303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978703800303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:15:16Z","timestamp":1777371316000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978703800303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,3]]}},"alternative-id":["10.1177\/000331978703800303"],"URL":"https:\/\/doi.org\/10.1177\/000331978703800303","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}