{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:06:16Z","timestamp":1777399576820,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1987,5,1]],"date-time":"1987-05-01T00:00:00Z","timestamp":546825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:p>\n                    The authors evaluated the relationship between sympathetic nerve activity and transcutaneous oxygen tension (TcpO\n                    <jats:sub>2<\/jats:sub>\n                    ) in normal and ischemic lower extremities. Dorsal foot TcpO\n                    <jats:sub>2<\/jats:sub>\n                    was measured by using oxygen-sensing electrodes with surface temperatures of 42 \u00b0 C and 45\u00b0C; in theory, changes in sympathetic activity should affect vasomotor tone and TcpO\n                    <jats:sub>2<\/jats:sub>\n                    in skin beneath an electrode at 42 \u00b0C (submaximal vasodilation), but not at 45\u00b0C (maximal vasodilation). The vasodilation index (TcpO\n                    <jats:sub>2<\/jats:sub>\n                    at 42\u00b0C\/TcpO\n                    <jats:sub>2<\/jats:sub>\n                    at 45\u00b0C) was created as an index of vasomotor tone (vasodilation index increases as tone decreases). In normal limbs (n=24) averages for TcpO\n                    <jats:sub>2<\/jats:sub>\n                    at 42\u00b0C, TcpO\n                    <jats:sub>2<\/jats:sub>\n                    at 45\u00b0C, and vasodilation index were 30.3 mmHg, 62.1 mmHg, and 0.47, respectively. In subjects (n=5) with quadriplegia and reduced sympathetic tone secondary to cervical cord trauma, TcpO\n                    <jats:sub>2<\/jats:sub>\n                    at 42 \u00b0 C and vasodilation index were increased (45.0 mmHg and 0.61); TcpO\n                    <jats:sub>2<\/jats:sub>\n                    at 45 \u00b0 C did not change. When normal subjects (n=7) were chilled for twenty minutes with a cooling blanket at 5 \u00b0 C (to increase sympathetic tone) average vasodilation index dropped from 0.50 to 0.29. Among ischemic limbs (n = 34) vasodilation index was highly variable (range: 0-0.77); in general, vasodilation index fell as the ischemia worsened. In a subset of patients with ischemic limbs, the vasodilation index increased after the limb was wrapped in a warm dressing (average vasodilation index=0.25without dressing, 0.37 with dressing). The authors conclude: (1) TcpO\n                    <jats:sub>2<\/jats:sub>\n                    can be used to assess the degree of vasomotor tone (and sympathetic activity) in skin; (2) tone generally increases as ischemia worsens; and (3) local warmth can improve cutaneous circulation in ischemic limbs.\n                  <\/jats:p>","DOI":"10.1177\/000331978703800508","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"400-410","source":"Crossref","is-referenced-by-count":27,"title":["The Influence of Sympathetic Nerves on Transcutaneous Oxygen Tension in Normal and Ischemic Lower Extremities"],"prefix":"10.1177","volume":"38","author":[{"given":"Thom W.","family":"Rooke","sequence":"first","affiliation":[{"name":"Mayo Clinic and Mayo Foundation, Division of Cardiovascular Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry H.","family":"Hollier","sequence":"additional","affiliation":[{"name":"Head, Section of Vascular Surgery, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Osmundson","sequence":"additional","affiliation":[{"name":"Mayo Clinic and Mayo Foundation, Division of Cardiovascular Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90099-X"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198303000-00014"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1088\/0143-0815\/4\/1\/006"},{"key":"atypb4","first-page":"339","volume":"95","author":"Wyss CR","year":"1984","journal-title":"Surgery"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1984.01390180054009"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198408000-00007"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90604-3"},{"issue":"8398","key":"atypb8","first-page":"329","volume":"2","year":"1984","journal-title":"Lancet"},{"key":"atypb9","unstructured":"Ryan TJ: Dermal vasculature. In: Methods in Skin Research, ed. by Skerrow D and Skerro CJ. London, John Wiley & Sons, Ltd., 1985, pp. 527-558."},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.65B1.6822606"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90014-X"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.3109\/00365518109090509"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1978.tb01386.x"},{"key":"atypb14","unstructured":"Fairbairn JF, Joyce JW, Pairolero PC: Acute arterial occlusion of the extremities. In: Peripheral Vascular Diseases, ed. by Juergens JL, Spittell JA, Fairbairn JF. Philadelphia, W.B. Saunders Co., 1980, pp. 391-392."},{"key":"atypb15","first-page":"291","volume":"20","author":"Clement DL","year":"1979","journal-title":"J Cardiovasc Surg"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12497938"},{"key":"atypb17","unstructured":"Shepherd JT, Vanhoutte PM: The Human Cardiovascular System. New York, Raven Press, 1979, pp. 91-106."},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1042\/cs068s121"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(84)90127-7"},{"key":"atypb20","unstructured":"Juergens JL, Bernatz PE: Atherosclerosis of the extremities. In: Peripheral Vascular Diseases, ed. by Juergens JL, Souttell JA, Fairbaird JF. Philadelphia, W.B. Saunders Co., 1980, pp. 261-293."},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)41891-8"},{"key":"atypb22","first-page":"164","volume":"53","author":"Blain A.","year":"1963","journal-title":"Surgery"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1967.01330170061008"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195311000-00012"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(73)90024-3"},{"key":"atypb26","first-page":"772","volume":"33","author":"Carey JP","year":"1967","journal-title":"Am Surg"},{"key":"atypb27","first-page":"82","volume":"82","author":"Cronenwett JL","year":"1977","journal-title":"Surgery"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194712000-00004"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978703800508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978703800508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:15:23Z","timestamp":1777371323000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978703800508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,5]]}},"alternative-id":["10.1177\/000331978703800508"],"URL":"https:\/\/doi.org\/10.1177\/000331978703800508","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}