{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:07:51Z","timestamp":1777399671193,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1987,9,1]],"date-time":"1987-09-01T00:00:00Z","timestamp":557452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:p>Milrinone (M) has been shown to improve left ventricular (LV) performance in animal and human studies. M has strong vasodilator action, and whether increased LV performance is due primarily to vasodilation or to a direct positive inotropic effect is unclear.<\/jats:p>\n                  <jats:p>Ten mongrel dogs were studied. Disopyramide caused a significant and sus tained decrease in LV function and was a good model for myocardial depres sion. At equal reduction in systemic vascular resistance (SVR), M reversed this LV depression to a significantly greater degree than nitroprusside (NP) did.<\/jats:p>\n                  <jats:p>At equal levels of vasodilation, M produced significantly greater improve ment in indices of LV function than NP did in our model of disopyramide- induced LV failure. This suggests that its effect on LV function is not due entirely to afterload reduction, or to reflex sympathetic stimulation, but has a substantial component of direct inotropic stimulation. This study also demon strated a reversal of disopyramide-induced LV dysfunction by M, which may be clinically useful since, as in many antiarrhythmics, myocardial depression may be a limiting factor in its use.<\/jats:p>","DOI":"10.1177\/000331978703800902","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"657-662","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Vasodilator vs Inotropic Effect of Milrinone Using an Animal Model of Left Ventricular Failure: Reversal of Disopyramide Depression of the Myocardium with Milrinone"],"prefix":"10.1177","volume":"38","author":[{"given":"Emanuel","family":"Goldberg","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Beth Israel Medical Center, Mount Sinai School of Medicine, City University of New York, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Berdoff","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Beth Israel Medical Center, Mount Sinai School of Medicine, City University of New York, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Spivack","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Beth Israel Medical Center, Mount Sinai School of Medicine, City University of New York, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azriel","family":"Haimowitz","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Beth Israel Medical Center, Mount Sinai School of Medicine, City University of New York, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Tay","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Beth Israel Medical Center, Mount Sinai School of Medicine, City University of New York, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,9,1]]},"reference":[{"key":"atypb1","first-page":"663","volume":"40","author":"Alousi AA","year":"1981","journal-title":"Fed Proc"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198309293091302"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)90145-6"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198309000-00014"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198003133021106"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.60.5.1053"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90014-4"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(72)90069-5"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.5.972"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.6.1030"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111742"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978703800902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978703800902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:15:30Z","timestamp":1777371330000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978703800902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1987,9]]}},"alternative-id":["10.1177\/000331978703800902"],"URL":"https:\/\/doi.org\/10.1177\/000331978703800902","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,9]]}}}