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The disparate pulmonary hemodynamic responses to calcium channel blockade reported herein suggest that CREST patients with mild pulmonary hypertension may have a component of reversible vasospasm responsive to vasodilator therapy, whereas patients with moderate to severe puhnonary hypertension may have fixed vessel lesions precluding a satisfactory response to calcium channel blockade.<\/jats:p>","DOI":"10.1177\/000331978803900410","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"385-389","source":"Crossref","is-referenced-by-count":1,"title":["Value and Limitations of Calcium Channel Blockade In the Treatment of Pulmonary Hypertension Associated with CREST \u2014 Case Reports"],"prefix":"10.1177","volume":"39","author":[{"given":"Thomas A.","family":"Pressly","sequence":"first","affiliation":[{"name":"Departments of Medicine, University of Missouri Health Sciences Center and Harry S. 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