{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:11:25Z","timestamp":1777399885079,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1988,7,1]],"date-time":"1988-07-01T00:00:00Z","timestamp":583718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:p>Now progressive systemic sclerosis (PSS) is considered a disease of small vessels with which many immunologic alterations are associated. The presence in the blood of large amounts of serotonin can be considered a very important aggravating factor able to cause the sclerodermic alterations.<\/jats:p>\n                  <jats:p>\n                    The authors have treated 10 PSS patients with ketanserin, a selective antagonist of the S\n                    <jats:sub>2<\/jats:sub>\n                    serotonin receptors, which are found in small vessels and platelets.\n                  <\/jats:p>\n                  <jats:p>Their results show that ketanserin represents an efficacious and very well tolerated therapy for treatment of the initial vascular symptoms of PSS.<\/jats:p>","DOI":"10.1177\/000331978803900705","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"583-586","source":"Crossref","is-referenced-by-count":5,"title":["Ketanserin in the Treatment of Progressive Systemic Sclerosis"],"prefix":"10.1177","volume":"39","author":[{"given":"G.F.","family":"Altomare","sequence":"first","affiliation":[{"name":"From the 2nd Department of Dermatology, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.D.","family":"Pigatto","sequence":"additional","affiliation":[{"name":"From the 2nd Department of Dermatology, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Polenghi","sequence":"additional","affiliation":[{"name":"From the 2nd Department of Dermatology, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.149.6.1326"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-4-482"},{"key":"atypb3","volume":"4","author":"Campbell PM","year":"1975","journal-title":"Seminaria of Arthritis Rheumatoides"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-5-788"},{"key":"atypb5","volume-title":"Scleroderma Symposium","author":"Summers GD"},{"key":"atypb6","volume-title":"Atti III Simposium International Immunopatologia cutanea","author":"Altomare GF"},{"key":"atypb7","author":"Pagano L.","year":"1985","journal-title":"Clinical Experimental Rheumatology"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270204"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1177\/000331976001100301"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1986.tb02244.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-028024-0.50006-2"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-57-2-198"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1976.tb15534.x"},{"key":"atypb14","volume-title":"Ketanserin: a novel serotonin S2-Receptors blocking agent. Investigatial New Drug Brochure","author":"Janssen Pharmaceutica","year":"1983"},{"key":"atypb15","volume":"285","author":"Stranden E.","year":"1969","journal-title":"British Medical Journal"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978803900705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978803900705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:16:01Z","timestamp":1777371361000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978803900705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1177\/000331978803900705"],"URL":"https:\/\/doi.org\/10.1177\/000331978803900705","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}