{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:14:25Z","timestamp":1777400065936,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1989,5,1]],"date-time":"1989-05-01T00:00:00Z","timestamp":609984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:p>The effect of nifedipine (N) on sinus node (SN) function was studied in 15 patients (9 males, 6 females) sixty-two to seventy-six (mean 68.1 \u00b111) years old, with sick sinus syndrome (SSS). SSS was characterized electrophysiologically by a prolonged corrected sinus node recovery time (CSNRT &gt; 535 msec) and\/or prolonged sinoatrial conduction time (SACT &gt; 125 msec), assessed by applying premature atrial stimulation. Ten mg N was given sublingually, and CSNRT and SACT were again evaluated sixty minutes after N administration, and again ten minutes after 1.5 mg atropine (A) was given IV. Heart rate increased significantly after N (p &lt; 0.005), systolic blood pressure (SBP) diminished sig nificantly (p &lt; 0.005), and CSNRT and SACT shortened significantly (p &lt; 0.005, p &lt; 0.005) and became normal in 7 and 5 patients respectively. After A administration, a further significant increase of heart rate (p &lt; 0.005) and decrease of CSNRT (p &lt; 0.005) and SACT (p &lt; 0.005) were observed. CSNRT and SACT became normal in 8 and 7 patients respectively. SBP remained sta ble.<\/jats:p>","DOI":"10.1177\/000331978904000505","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"450-457","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Nifedipine on the Sick Sinus Syndrome"],"prefix":"10.1177","volume":"40","author":[{"given":"George","family":"Kouvaras","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Chronopoulos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Periklis","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Sofronas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Cokkinos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,5,1]]},"reference":[{"key":"atypb1","first-page":"22","volume":"22","author":"Fleckenstein A.","year":"1972","journal-title":"Drug Res"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.17.040177.001053"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90202-8"},{"key":"atypb4","unstructured":"Pop T., Treese N., Schuster CJ, et al: Effects of nifedipine on sino-atrial and atrioventricular node function after autonomic blockade in man. In: Sixth International Adalat Symposium, ed. by Lichtlen PR. Amsterdam, Excerpta Medica, 1986 , p 92."},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(66)90073-7"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1978.tb02203.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(83)80120-9"},{"key":"atypb8","unstructured":"Schulz W., Kaltenbach M., Kober G.: Chronotropic response after injection of nifedipine into the sinus-node artery in man. In: Fifth International Adalat Symposium, ed. by Kaltenbach M, Neufeld HN. Amsterdam, Excerpta Medica, 1983, p 322."},{"key":"atypb9","first-page":"29","volume":"2","author":"Taburet AM","year":"1983","journal-title":"Hypertension"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.5.763"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1979.236.1.C1"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1038\/285228a0"},{"key":"atypb13","unstructured":"Treese N., Kasper W., Pop T., et al: Depressive effect of diltiazem on sinus node function after autonomic blockade in man. In: Calcium Antagonists. Recent Development and Prospects, ed. by Fleckenstein A, Hashimoto K, Hermann M, et al: Stuttgart, 1983, p 213."},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-9715-8_11"},{"key":"atypb15","first-page":"33","volume":"22","author":"Raff WK","year":"1972","journal-title":"Drug Res"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67595-9_28"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.1.124"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a061424"},{"issue":"2","key":"atypb19","first-page":"109","volume":"59","author":"Littler WA","year":"1983","journal-title":"Postgrad Med"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.86.1.14"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.63.5.1035"},{"key":"atypb22","first-page":"290","volume":"17","author":"Padeletti L.","year":"1979","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"atypb23","unstructured":"Furlanello F. , Disertori M., Vergara G., et al: Study on the electrophysiological effects of nifedipine in man. In: Fourth International Adalat Symposium. New Therapy of Ischemic Heart Disease, ed. by Puech P, Krebs R. Amsterdam, Excerpta Medica, 1980 , p 227."},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1007\/BF00499993"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198325020-00003"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.37.9.956"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1007\/BF01914656"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90874-7"},{"key":"atypb29","first-page":"395","volume":"7","author":"Kouvaras G.","year":"1984","journal-title":"Iatrika Chronika"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1977225part1528"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)91123-9"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978904000505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331978904000505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:16:46Z","timestamp":1777371406000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331978904000505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,5]]}},"alternative-id":["10.1177\/000331978904000505"],"URL":"https:\/\/doi.org\/10.1177\/000331978904000505","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,5]]}}}