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After a washout phase of one week, the patients received in accordance with a randomization scheme either an i.v. infusion of 300 mg of pentoxifylline (15 mL am poules) or 15 mL of a 0.9% NaCl so lution in 250 mL of 5% laevulose, administered over three hours twice daily. The main efficacy parameters were treadmill-assessed initial claudi cation distance (ICD) and absolute claudication distance (ACD). Base line testing revealed a mean ICD of 131 m in the pentoxifylline group and 126 m in the placebo cohort; mean ACD values were 239 m and 225 m respectively. The group of patients treated with pentoxifylline (n=75) displayed a significantly greater im provement (p &lt; 0.0001) in ICD (+70%) and ACD (+60%) than the placebo group did (+33% and 32%, respectively) (n=79). The infusions were well tolerated in both groups.<\/jats:p>","DOI":"10.1177\/000331978904000706","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"639-649","source":"Crossref","is-referenced-by-count":12,"title":["Intravenous Treatment of Chronic Peripheral Occlusive Arterial Disease: A Double-Blind, Placebo-Controlled, Randomized, Multicenter Trial of Pentoxifylline"],"prefix":"10.1177","volume":"40","author":[{"given":"G.","family":"Rudofsky","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University Ulm, Ulm, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.F.","family":"Haussler","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Kreiskrankenhaus (District Hospital) Ammerland, Westerstede, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.P.","family":"K\u00fcnkel","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Kreiskrankenhaus (District Hospital) Eutin, M\u00fchlenberg-Klinik, Malente, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Schneider-May","sequence":"additional","affiliation":[{"name":"Surgical Department, Evang. 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