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Extensive review of reports indicates this has resulted from observations of either (1) inordinate incidence of MVP in well-defined neurologic entities or (2) development of neurologic or ophthalmologic complications attributed to MVP. In the review presented, basis is found for categorizing MVP by its association with (1) well-defined, genetically determined neurologic disorders; (2) disorders characterized by structural abnormalities, many genetically determined, or inflammatory processes of connective tissues; (3) \"mechanical\" prolapse resulting from disproportion of mitral valve annulus and left ventricular size, which is, at times, reversible; and (4) a generally asymptomatic state that, at times, is associated with ischemic, thrombotic, embolic, and infectious disorders of the brain and eye. The paradox between the large number of persons with MVP in the general population who remain healthy and a subpopulation of patients with complications of MVP (eg, stroke) or other entities has been identified. A second paradox is found between the well-known increased incidence of MVP, especially in young patients with stroke, and the apparent rarity of stroke among patients with both common (eg, migraine) and unusual (eg, myotonic dystrophy) neurologic entities in which an extraordinary high prevalence of MVP is known to exist.<\/jats:p>","DOI":"10.1177\/000331978904000810","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"743-751","source":"Crossref","is-referenced-by-count":6,"title":["35th Annual Meeting \u2014 American College of Angiology Orlando, Florida \u2014 October, 1988 Symposium Proceedings"],"prefix":"10.1177","volume":"40","author":[{"given":"Albert F.","family":"Heck","sequence":"first","affiliation":[{"name":"Department of Neurology, West Virginia University School of Medicine, Charleston Division, and Charleston Area Medical Center, Charleston, West 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