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The purpose of this study was to directly observe and quantitate the effect of pentoxifylline on the flow of individual PMNs into a model capillary. Short-term incubation of human PMNs with 10 mM pentoxifylline inhibited cell activation, as judged by a significant reduction in the number of neutrophils forming pseudopods. Furthermore, incubation of PMNs from 6 healthy men with 0.1, 1.0 and 10 mM pentoxifylline significantly decreased the time required for individual cells to be aspirated into a 4 \u03bcm pipet under constant pressure by 16 \u00b1 5%, 21 \u00b1 7%, and 41 \u00b1 8%, respectively (mean \u00b1 SEM, p\u22640.05), compared with control. These experiments are the first direct demonstration of increased deformability in neutrophils treated with pentoxifylline. The results are consistent with the hypothesis that the beneficial effect of pentoxifylline on microvascular perfusion is partly due to an inhibition of PMN stiffness and activation.<\/jats:p>","DOI":"10.1177\/000331979004100401","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"253-262","source":"Crossref","is-referenced-by-count":26,"title":["Effect of Pentoxifylline on the Flow of Polymorphonuclear Leukocytes Through a Model Capillary"],"prefix":"10.1177","volume":"41","author":[{"suffix":"JR","given":"Michael","family":"Armstrong","sequence":"first","affiliation":[{"name":"Departments of Ophthalmology and Cell Biology, Duke University Medical Center, and Durham Veteran's Administration Medical Center, Durham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Needham","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane Lillian","family":"Hatchell","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology and Cell Biology, Duke University Medical Center, and Durham Veteran's Administration Medical Center, Durham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi Saxena","family":"Nunn","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1984.tb03380.x"},{"key":"atypb2","first-page":"401","volume":"19","author":"Ehrly AM","year":"1982","journal-title":"IRCS J Med Sci"},{"key":"atypb3","first-page":"1","volume":"18","author":"Rossner M.","year":"1987","journal-title":"J Med"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90642-1"},{"key":"atypb5","first-page":"159","volume":"5","author":"Sch\u00f6nharting M.","year":"1988","journal-title":"Pharmatherapeutica"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V64.2.542.542"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.3233\/CH-1985-5511"},{"key":"atypb8","unstructured":"Nees S., Sch\u00f6nharting M.: Role of different blood cell types in blood rheology. 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