{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:57:04Z","timestamp":1777399024308,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:p>Plugging of skin capillaries by activated white blood cells is one of the proposed mechanisms by which skin damage may be initiated in chronic venous insuffi ciency . The aim of this study was to determine whether a microcirculatory deficit was induced in the skin by raising the venous pressure proximally for thirty minutes.<\/jats:p>\n                  <jats:p>Seventeen subjects with no evidence of venous or arterial disease had laser Doppler velocimetry performed in the gaiter region of the leg; 8 different subjects had the measurement done on the dorsum of the hand. Peak hyperemic response following three minutes of ischemia was measured before and after a thirty-min ute period of sustained venous hypertension applied by a proximal tourniquet inflated to 80 mm Hg.<\/jats:p>\n                  <jats:p>A decrease in the peak flow: baseline flow ratio (median ratio 2.25 before, 1.70 after, p &lt;0.02) and an increase in the time taken to reach maximal hyperemia (median time ten seconds before, twenty seconds after, p&lt;0.01) were observed after the period of venous hypertension in the lower limb . The second parameter, but not the first, was significantly affected in the upper limb .<\/jats:p>\n                  <jats:p>The authors conclude that a microvascular deficit in the skin is demonstrable after a short period of venous hypertension . This is consistent with the white-cell- trapping theory, but other possible explanations are discussed.<\/jats:p>","DOI":"10.1177\/000331979104200205","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:46:29Z","timestamp":1196099189000},"page":"114-122","source":"Crossref","is-referenced-by-count":5,"title":["The Effect on Skin Blood Flow of Short-Term Venous Hypertension in Normal Subjects"],"prefix":"10.1177","volume":"42","author":[{"given":"T.R.","family":"Cheatle","sequence":"first","affiliation":[{"name":"Vascular Laboratory, Department of Surgery, University College and Middlesex School of Medicine, Middlesex Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.J.","family":"Chittenden","sequence":"additional","affiliation":[{"name":"Vascular Laboratory, Department of Surgery, University College and Middlesex School of Medicine, Middlesex Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.D.","family":"Coleridge Smith","sequence":"additional","affiliation":[{"name":"Vascular Laboratory, Department of Surgery, University College and Middlesex School of Medicine, Middlesex Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Scurr","sequence":"additional","affiliation":[{"name":"Vascular Laboratory, Department of Surgery, University College and Middlesex School of Medicine, Middlesex Hospital, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,2,1]]},"reference":[{"key":"atypb1","first-page":"300","volume":"24","author":"Homans J.","year":"1917","journal-title":"Surg Gynecol Obstet"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1929.01150050129010"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/000331975300400108"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(77)90187-1"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(86)90411-8"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90325-7"},{"key":"atypb7","first-page":"372","volume":"78","author":"Dodd HJ","year":"1985","journal-title":"JR Soc Med"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6638.1726"},{"key":"atypb9","first-page":"311","volume":"5","author":"Moyses C.","year":"1987","journal-title":"Int J Micro-circ Clin Exp"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6638.1693"},{"key":"atypb11","first-page":"101","volume":"11","author":"Fagrell B.","year":"1982","journal-title":"Casa"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1177\/026835558600100302"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1126\/science.186.4166.830"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12507665"},{"key":"atypb15","volume-title":"On laser Doppler flowmetry. Linkoping University Medical Dissertation","author":"Tenland T.","year":"1982"},{"key":"atypb16","first-page":"277","volume":"2","author":"Tooke JE","year":"1983","journal-title":"Int J Microcirc Clin Exp"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/000331978603701105"},{"key":"atypb18","first-page":"37","volume":"7","author":"Ostergren J.","year":"1988","journal-title":"Int Angiology"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6531.1295"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6513.87"},{"key":"atypb21","volume-title":"Impaired hyperaemic response in the microcirculation in patients with venous leg ulcers. Forum on clinical haemorheology abstract","author":"Tanner R.","year":"1989"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1177\/026835558900400304"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1976.tb10284.x"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.3109\/00365517309102352"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979104200205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979104200205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:14:12Z","timestamp":1777371252000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331979104200205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2]]}},"alternative-id":["10.1177\/000331979104200205"],"URL":"https:\/\/doi.org\/10.1177\/000331979104200205","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,2]]}}}