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In spite of its generally benign character, it causes a lot of discomfort to individuals and sick ness absenteeism to society, especially in the colder regions of the world.<\/jats:p>\n                  <jats:p>The etiology remains an enigma 130 years after its first description, perhaps even more so than ever before, the many new theories proposed in the litera ture. Clearly, in a condition where seventy different etiologic theories are advo cated, the culprit lesion is obviously missing, or there is not a culprit lesion but an accumulation of conditions having nothing in common but a few symptoms. Moreover a Raynaud attack may result, not from a single event, but from a cascade of events, just as, for example, hemostasis does.<\/jats:p>\n                  <jats:p>Controversy about diagnosis exists all over. For example, how does one make a diagnosis? Patient history has been considered unreliable. A standardized cold test, though highly reproducible in the authors' hands, is far from common property.<\/jats:p>\n                  <jats:p>Raynaud's syndrome is a condition for which thirty-eight therapies have been advocated in the last three years, but the curative answer is still to come.<\/jats:p>","DOI":"10.1177\/000331979304400305","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"196-209","source":"Crossref","is-referenced-by-count":10,"title":["Raynaud's Syndrome, an Enigma After 130 Years"],"prefix":"10.1177","volume":"44","author":[{"given":"Ton J. 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