{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:11:47Z","timestamp":1777399907665,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:p>Protein C deficiency is a cause of thromboembolic disease. Venous thrombosis is the most common clinical manifestation. Arterial thrombosis is unusual and involvement of the intracranial arteries is especially rare. Herein the authors describe a case of cerebellar infarction associated with protein C deficiency and review the relevant medical literature. A thirty-year-old man was hospitalized because of dysarthria, right limb ataxia, and a gait disturbance. Cranial computed tomography disclosed an infarction in the right cerebellar hemisphere and brachium pontis. Three months earlier the patient had had a transient ischemic attack with truncal ataxia and gait disturbances. On admission, the protein C antigen was 57% and protein C activity was 45%. Investigation of family members revealed protein C deficiency in an uncle. Literature review of stroke cases associated with protein C deficiency revealed that most had had a previous vascular event and\/or a positive family history or had used oral contraceptives chronically. Protein C deficiency should be considered in young stroke patients with a positive family history of vasooc clusive disease, previous ischemic events, or chronic oral contraceptive use.<\/jats:p>","DOI":"10.1177\/000331979504600212","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"169-173","source":"Crossref","is-referenced-by-count":5,"title":["Cerebral Infarction in a Young Adult Associated with Protein C Deficiency"],"prefix":"10.1177","volume":"46","author":[{"given":"Hiroyuki","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and General Medicine, Saga Medical School, Saga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Shirahama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and General Medicine, Saga Medical School, Saga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Ohmori","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and General Medicine, Saga Medical School, Saga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Sunaga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and General Medicine, Saga Medical School, Saga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00645a029"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605153142006"},{"key":"atypb3","first-page":"15","volume":"543","author":"Conard J.","year":"1988","journal-title":"Acta Chir Scand"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110385"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90220-8"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6454.1285"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.7.5.456"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(72)90570-0"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(86)90145-3"},{"key":"atypb10","first-page":"71","volume":"8","author":"Comp PC","year":"1986","journal-title":"Prog Hemost Thromb"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.8.1111"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.7.1077"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.1.108"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90750-5"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6465.350"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1660166"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830290211"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80014-3"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.1.135"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320774"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830330112"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1007\/BF01703145"},{"key":"atypb23","first-page":"727","author":"Royal College of General Practitioners' oral contraception study","year":"1977","journal-title":"Lancet"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979504600212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979504600212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:16:08Z","timestamp":1777371368000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331979504600212"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["10.1177\/000331979504600212"],"URL":"https:\/\/doi.org\/10.1177\/000331979504600212","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2]]}}}