{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:11:41Z","timestamp":1777399901437,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:p>In this study the efficacy and safety femoral intra-arterial administration of teicoplanin in the treatment of diabetic foot infections caused by gram-positive bacteria were evaluated. Twenty-five hospitalized diabetic patients with foot ulcers or with foot ulcers and metatarsophalangeal osteomyelitis were included in the study.<\/jats:p>\n                  <jats:p>In the ulcers Staphylococcus aureus was present alone in 16 patients and was associ ated with Pseudomonas aeruginosa in 2 patients, with Candida albicans in 2, and with coagulase-negative Staphylococcus in 1 patient. In 4 patients other gram-positive bacteria were isolated. All isolated strains were resistant to various antibiotics tested. Teicoplanin, 200 mg, was administered once a day by femoral intra-arterial injection for an average period of 14.72 \u00b17.16 days (range ten to thirty-six days). Six patients were treated with an additional antibiotic intramuscularly or intravenously because of a mixed infection. At the end of the therapy microbiological assessment confirmed that gram-positive infection was eliminated in all patients. Clinical outcome demonstrated that healing occurred in 18 patients (72%) and improvement in 7 patients (28%).<\/jats:p>\n                  <jats:p>No adverse drug reactions were observed during the treatment. The results demon strate that femoral intra-arterial administration of teicoplanin was highly effective in skin- and bone-infected lesions in the diabetic foot. This method may represent a further advantage in management of this severe diabetic complication.<\/jats:p>","DOI":"10.1177\/000331979504601207","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"1115-1122","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Femoral Intra-arterial Administration of Teicoplanin in Gram-Positive Diabetic Foot Infections"],"prefix":"10.1177","volume":"46","author":[{"given":"Bruno","family":"Dorigo","sequence":"first","affiliation":[{"name":"Institute of Internal Medicine , University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Cameli","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine , University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Trapani","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine , University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinella","family":"Raspanti","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine , University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Torri","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine , University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Mosconi","sequence":"additional","affiliation":[{"name":"Marion Merrell Dow Inc., Medical Department, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800720102"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1985.tb00683.x"},{"key":"atypb3","first-page":"671","volume":"110","author":"Seabrook GR","year":"1991","journal-title":"Surgery"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/000331978003100401"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1017\/S0195941700065917"},{"key":"atypb6","first-page":"20","volume":"72","author":"Felmingham D.","year":"1990","journal-title":"Scand J Infect Dis"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/16.6.743"},{"issue":"1","key":"atypb8","first-page":"23","volume":"1","author":"Concia E.","year":"1988","journal-title":"Antibioticoterapia pratica"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/21.suppl_A.61"},{"key":"atypb10","volume-title":"Proceedings of the 17th ICC","author":"Dorigo B."},{"key":"atypb11","unstructured":"Wagner FW: Algorithms of diabetic foot care. In: The Diabetic Foot, ed. by Levin ME, O'Neal FW. St. Louis: CV Mosby, 1983, p291."},{"key":"atypb12","volume-title":"Methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically: Approved Standard M7-S2","author":"National Committee for Clinical Laboratory Standards","year":"1990"},{"key":"atypb13","volume-title":"Performance standards for antimicrobial disk susceptibility tests. Approved Standard M2-A4","author":"National Committee for Clinical Laboratory Standards","year":"1990"},{"issue":"1","key":"atypb14","volume":"6","author":"Sapico FL","year":"1984","journal-title":"Rev Infect Dis"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1985.tb00640.x"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(88)90183-7"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390160058013"},{"key":"atypb18","volume-title":"Infezioni da Gram-positivi. 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