{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:14:25Z","timestamp":1777400065310,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1996,6,1]],"date-time":"1996-06-01T00:00:00Z","timestamp":833587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:p>Heparinization is a routine procedure during angioplasty; however, its consequences on the late vascular response to a severe injury are unclear. The authors' objective was to explore the effect of a single heparin bolus at the time of a severe vascular injury on late intimal proliferation and neointimal thickening. The iliac artery of 57 normolipemic rabbits was overdistended with a balloon catheter. Heparin (250 IU\/kg IV) was given to 29 rabbits ten minutes before angioplasty, whereas 28 rabbits served as untreated controls. Neointimal thickening was prominent at fourteen days after injury and reached near-maximal values at day 28. The intimal\/medial area ratio was reduced by an average 28.3% with heparin (at day 28: 2.19 \u00b1 0.51 vs 1.57 \u00b1 0.59, control vs heparin, P = 0.02). Neointimal cells stained positively for HHF-35 antibody, directed against smooth muscle cell antigens. Neointimal proliferation, quantified through the number of cell nuclei peroxidase-stained for PCNA\/cyclin antigen, was significantly decreased by 43% and 49% with heparin, respectively, at days 7 and 14 after injury. These data suggest that early exposure even to low doses of heparin accounts for much of its inhibitory effect in vascular response to injury; such an effect might prove important in interpreting results of human trials of interventions against restenosis.<\/jats:p>","DOI":"10.1177\/000331979604700603","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"549-556","source":"Crossref","is-referenced-by-count":5,"title":["Effects of a Single Heparin Bolus on Neointimal Growth After Arterial Injury in Intact Rabbits"],"prefix":"10.1177","volume":"47","author":[{"given":"Mariano","family":"Janiszewski","sequence":"first","affiliation":[{"name":"Heart Institute, University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco R. M.","family":"Laurindo","sequence":"additional","affiliation":[{"name":"Heart Institute, University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Pasqualucci","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prot\u00e1sio L.","family":"da Luz","sequence":"additional","affiliation":[{"name":"Heart Institute, University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00falvio","family":"Pileggi","sequence":"additional","affiliation":[{"name":"Heart Institute, University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.58.4.427"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/1050-1738(94)90054-X"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/1050-1738(93)90042-5"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.3.723"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.67.3.651"},{"key":"atypb6","first-page":"208","volume":"49","author":"Clowes AW","year":"1983","journal-title":"Lab Invest"},{"key":"atypb7","first-page":"327","volume":"49","author":"Clowes AW","year":"1983","journal-title":"Lab Invest"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.7.1191"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1038\/265625a0"},{"key":"atypb10","first-page":"611","volume":"52","author":"Clowes AW","year":"1985","journal-title":"Lab Invest"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.58.6.839"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.46.5.625"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.4.1548"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.5.1657"},{"key":"atypb15","first-page":"615","volume":"39","author":"Anderson HV","year":"1993","journal-title":"DM"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116085"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.2.770"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.4.700"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.6.3.265"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.61.2.296"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.68.1.106"},{"key":"atypb22","first-page":"1017","volume":"140","author":"Olson NE","year":"1992","journal-title":"Am J Pathol"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.71.3.577"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.232"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.432"},{"issue":"1","key":"atypb26","first-page":"47","volume":"17","author":"Nader HB","year":"1991","journal-title":"Semin Thromb Hemost"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50582-8"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.70.6.1128"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117191"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1042\/bj2860717"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.5.1705"},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.CIR.90.1.1","volume":"90","author":"Janiszewski M.","year":"1994","journal-title":"Circulation"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979604700603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979604700603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:16:46Z","timestamp":1777371406000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331979604700603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,6]]}},"alternative-id":["10.1177\/000331979604700603"],"URL":"https:\/\/doi.org\/10.1177\/000331979604700603","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,6]]}}}