{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:51:09Z","timestamp":1777398669948,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:p>A severe thrombotic thrombocytopenic status, induced by heparin in a sixty-nine-year-old woman undergoing total hip joint arthroplasty, was treated by switching the anticoagu lant therapy to coumarin, which induced skin necrosis. There appeared to be a possible causal relation between the severe immune reaction to heparin and the condition that predisposed to skin necrosis in the presence of coumarin. In patients who express a strong immune response to heparin, a different anticoagulant approach other than use of coumarin congeners appears to be justified..<\/jats:p>","DOI":"10.1177\/000331979604700715","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"725-727","source":"Crossref","is-referenced-by-count":10,"title":["Coumarin-Induced Skin Necrosis Following Heparin-Induced Thrombocytopenia and Thrombosis A Case Report"],"prefix":"10.1177","volume":"47","author":[{"given":"Adi","family":"Shahak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emoke","family":"Posan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Sz\u00fccs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janos","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Boda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/000331978803901009"},{"key":"atypb2","first-page":"259","volume":"23","author":"Drakos P.","year":"1993","journal-title":"Haemostasis"},{"key":"atypb3","first-page":"271","volume":"103","author":"Cole MS","year":"1988","journal-title":"Surgery"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680110115020"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002682"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90179-F"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703053161004"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322011"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830360410"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440050095041"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979604700715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979604700715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:13:42Z","timestamp":1777371222000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331979604700715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["10.1177\/000331979604700715"],"URL":"https:\/\/doi.org\/10.1177\/000331979604700715","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}