{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:20:00Z","timestamp":1790374800447,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:p>\n                    Regional blood flow and oxygen uptake of the lower limbs were studied in 11 patients with arterial insufficiency (10 with severe unilateral, 1 with bilateral intermittent clau dication). Regional muscle blood flow (F), oxygen consumption rate (R), and oxygen extraction fraction (E) were evaluated by positron emission tomography (PET) and bolus inhalation of C\n                    <jats:sup>15<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and\n                    <jats:sup>15<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    by the patient. Tomograms were recorded at the greatest diameter of legs, at rest and ten minutes after a treadmill walk test leading to the devel opment of ischemic pain in the affected leg. In 5 patients, F and E were correlated with the results of occlusive venous strain gauge plethysmography and with the measure ments of blood gases in one brachial artery and in the femoral vein of the affected limb. Blood flow values measured at rest and after exercise by PET were poorly correlated with the plethysmographic findings. This may be because PET does not interfere with flow as venous occlusion plethysmography does in low peripheral pressure conditions.\n                  <\/jats:p>\n                  <jats:p>The results show that F, R, and E were not significantly different in normal and patho logic legs at rest. The values of F and R were significantly higher in pathologic than in normal lower limbs, ten minutes after exercise, whereas E was not significantly altered by exercise at any side. This suggests that, during the recovery from a walk test, the delayed increase in oxygen uptake is proportional to the delayed hyperemia in the ischemic muscles (\"oxygen debt\") and probably not linked to a luxury perfusion.<\/jats:p>","DOI":"10.1177\/000331979604701008","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"991-999","source":"Crossref","is-referenced-by-count":22,"title":["The Quantitation of Blood Flow\/Metabolism Coupling at Rest and After Exercise in Peripheral Arterial Insufficiency, Using PET and 15-0 Labeled Tracers"],"prefix":"10.1177","volume":"47","author":[{"given":"Mich\u00e8le","family":"Depairon","sequence":"first","affiliation":[{"name":"CHUV Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Zicot","sequence":"additional","affiliation":[{"name":"CHR Citadelle, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91518-1"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/2.2.161"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.39.3.353"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.118.4.814"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.118.4.820"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.125.3.628"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00253677"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.131.4.718"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.136.6.1179"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254343"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1177\/000331978703800405"},{"key":"atypb12","first-page":"458","volume":"30","author":"Oshima M.","year":"1989","journal-title":"J Nucl Med"},{"key":"atypb13","first-page":"1443","volume":"31","author":"Segall GM","year":"1990","journal-title":"J Nucl Med"},{"key":"atypb14","first-page":"1700","volume":"32","author":"Sayman HB","year":"1991","journal-title":"J Nucl Med"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106247"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-49-580-339"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198012000-00001"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1985.tb00289.x"},{"key":"atypb19","first-page":"70","volume":"12","author":"Lebas JJ","year":"1987","journal-title":"J Mal Vasc"},{"key":"atypb20","first-page":"152","volume":"3","author":"Depresseux JC","year":"1983","journal-title":"J Cereb Blood Flow Metab"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.28"},{"key":"atypb22","volume-title":"Mod\u00e8les et m\u00e9thodes cin\u00e9tiques en imagerie fonctionnelle m\u00e9dicale. Application \u00e0 l'\u00e9tude de circulation et du m\u00e9tabolisme du cerveau chez l'Homme par tomographie d'\u00e9mission positonique","author":"Depresseux JC","year":"1989"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1177\/000331979104201003"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-8878-1_3"},{"key":"atypb25","first-page":"307","author":"Blanc JM","year":"1986","journal-title":"Lancet"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1986.99"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1972.tb00657.x"},{"key":"atypb28","first-page":"283","volume":"37","author":"Zicot M.","journal-title":"Serano Symposia"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)92199-4"},{"key":"atypb30","first-page":"1","volume":"14","author":"Ehrly AM","year":"1986","journal-title":"Vasa"}],"container-title":["Angiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979604701008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000331979604701008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:16:30Z","timestamp":1777371390000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000331979604701008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["10.1177\/000331979604701008"],"URL":"https:\/\/doi.org\/10.1177\/000331979604701008","relation":{},"ISSN":["0003-3197","1940-1574"],"issn-type":[{"value":"0003-3197","type":"print"},{"value":"1940-1574","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10]]}}}