{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:55:45Z","timestamp":1777398945087,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angiology"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>\n                    The effect of enalapril on cerebral blood flow (CBF) was studied in 11 patients with chronic heart failure (NYHA II or III, dilated cardiomyopathy in 6 and old myocardial infarction in 5). CBF was evaluated by analyzing the Patlak-Plot curve obtained from radionuclide angiography with technetium-99m hexamethylpropylene amine oxime (\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-HM-PAO). Cardiac index (CI) and stroke volume (SV) were simultaneously measured by impedance cardiography. These measurements were performed before and at four weeks after daily administration of 5 mg enalapril. The stroke volume, cardiac index, and heart rate were not significantly changed after four weeks of enalapril admin istration. However, CBF was increased by 6.5% from 36.72 \u00b14.66 to 39.13 \u00b15.65 mL\/ 100g\/min (P&lt;0.05). These results suggest that enalapril increased cerebral blood flow, which was not related to increased cardiac output in congestive heart failure. Patlak-Plot analysis of radionuclide angiography using\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-HM-PAO may be available for quantitative assessment of brain perfusion.\n                  <\/jats:p>","DOI":"10.1177\/000331979704800806","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:57:07Z","timestamp":1217267827000},"page":"707-713","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Enalapril Maleate on Cerebral Blood Flow in Patients with Chronic Heart Failure"],"prefix":"10.1177","volume":"48","author":[{"given":"Hirotoshi","family":"Kamishirado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneo","family":"Fujito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Takayanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenori","family":"Morooka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Natsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Kamishirado","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Koshigaya Hospital Dokkyo University School of Medicine 2-1-50 Minamikoshigaya, Koshigaya Saitama 343, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90892-1"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90891-X"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/000331979204300502"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb00587.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.1"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-197902000-00012"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00173281"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1970.tb17735.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198020060-00001"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1159\/000186046"},{"key":"atypb11","unstructured":"Barnes FM, Barnes NM, Costrall B., et al: ACE inhibition and cognition. 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