{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:16:47Z","timestamp":1777421807394,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>\n                    As we recently found that IgA, IgM, and IgG are produced and secreted by immunocytes present in nasopharyngeal secretions, we tested the hypothesis that B- and T-lymphocytes in the surface secretions are derived from the nasopharyngeal tonsil in an active process. By immunohistochemistry, we found that numerous B- and T-lymphocytes were often accumulated in restricted areas in the epithelium, and some of these cells were demonstrated just beneath the epithelial surface or could be observed protruding into the lumen. A portion of these cells were Ki-67\n                    <jats:sup>+<\/jats:sup>\n                    , indicating clonal expansion and\/or immunoglobulin class switching. Analyses of the surface secretions by immunocytochemistry also demonstrated B- and T-lymphocytes, as well as Ki-67\n                    <jats:sup>+<\/jats:sup>\n                    cells \u2014 a finding that indicates that immunologically active cells are transported into the surface secretions. The results imply that there is a substantial migration from the nasopharyngeal tonsil of immunologically active cells into the surface secretions.\n                  <\/jats:p>","DOI":"10.1177\/000348940010900119","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"99-105","source":"Crossref","is-referenced-by-count":8,"title":["Nasopharyngeal Tonsil's Provision of the Surface Secretions with Immunocytes, a Property Additional to Antigen Processing"],"prefix":"10.1177","volume":"109","author":[{"given":"Magnus","family":"Ivarsson","sequence":"first","affiliation":[{"name":"G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Lundberg","sequence":"additional","affiliation":[{"name":"G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,1,1]]},"reference":[{"key":"bibr1-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1993.1294"},{"key":"bibr2-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1988.tb05291.x"},{"key":"bibr3-000348940010900119","first-page":"7","volume":"16","author":"Sorensen CH","year":"1990","journal-title":"APMIS"},{"key":"bibr4-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880260016004"},{"key":"bibr5-000348940010900119","unstructured":"Claeys S, Cuvelier C, Quatacker J, Van Cauwenberge P. Ultrastructural investigation of M-cells and lymphoepithelial contacts in naso-pharyngeal associated lymphoid tissue (NALT). Acta Otolaryngol Suppl (Stockh) 1996(suppl 523): 40\u20132."},{"key":"bibr6-000348940010900119","first-page":"1416","volume":"143","author":"Graeme CF","year":"1993","journal-title":"Am J Pathol"},{"key":"bibr7-000348940010900119","first-page":"361","volume":"39","author":"Korsrud FR","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"bibr8-000348940010900119","first-page":"111","volume":"185","author":"Perry ME","year":"1994","journal-title":"J Anat"},{"key":"bibr9-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1993.tb00145.x"},{"key":"bibr10-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400303"},{"key":"bibr11-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1038\/311071a0"},{"key":"bibr12-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)31639-X"},{"key":"bibr13-000348940010900119","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137812"},{"key":"bibr14-000348940010900119","doi-asserted-by":"crossref","unstructured":"Brandtzaeg P. Immunocompetent cells of the upper airway: functions in normal and diseased mucosa. Eur Arch Otorhinolaryngol Suppl 1995(suppl 1):S8-S21.","DOI":"10.1007\/BF02484429"},{"key":"bibr15-000348940010900119","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509133356"},{"key":"bibr16-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4101.51"},{"key":"bibr17-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.5.418"},{"key":"bibr18-000348940010900119","first-page":"895","volume-title":"Hematology","author":"Douglas SD","year":"1983","edition":"3"},{"key":"bibr19-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(91)90076-N"},{"key":"bibr20-000348940010900119","first-page":"657","volume":"99","author":"Ali MY","year":"1965","journal-title":"J Anat"},{"key":"bibr21-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530120304"},{"key":"bibr22-000348940010900119","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00326.x"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940010900119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940010900119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:18:15Z","timestamp":1777375095000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940010900119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1177\/000348940010900119"],"URL":"https:\/\/doi.org\/10.1177\/000348940010900119","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}