{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:48:27Z","timestamp":1792158507826,"version":"4.4.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>To assess the efficacy of low-dose methotrexate (MTX) given long-term for the treatment of autoimmune hearing loss, we performed a prospective open-label study of 11 patients with treatment-refractory autoimmune hearing loss. All patients had ongoing episodic worsening of hearing in 1 or both ears before enrollment despite traditional medical therapy. The MTX dose was 7.5 to 17.5 mg\/wk. Hearing loss and vertigo were evaluated at baseline and at completion of the study. Hearing improvement was defined as an improvement in the pure tone threshold (PT) average of &gt;10 dB or an increase in speech discrimination (SD) of &gt;15%, whereas worsening was defined as a worsening of &gt;10 dB in PT or a decrease of &gt;15% in SD in at least 1 ear. The MTX was well tolerated. Among the 6 patients with Meniere's disease, 4 had improvement or resolution of vertigo, while 2 had no improvement. Disequilibrium improved in all 3 patients with Cogan's syndrome. According to the parameters defined above, hearing improved in 9 patients (82%), was unchanged in 1 patient (9%), and worsened in 1 patient (9%). Long-term low-dose MTX therapy may be a useful therapy for some patients who have hearing loss with a presumptively autoimmune-mediated component that is refractory to traditional therapies.<\/jats:p>","DOI":"10.1177\/000348940010900802","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"710-714","source":"Crossref","is-referenced-by-count":35,"title":["Use of Methotrexate for Autoimmune Hearing Loss"],"prefix":"10.1177","volume":"109","author":[{"given":"Eric L.","family":"Matteson","sequence":"first","affiliation":[{"name":"Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oltita","family":"Tirzaman","sequence":"additional","affiliation":[{"name":"Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kasperbauer","sequence":"additional","affiliation":[{"name":"Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Facer","sequence":"additional","affiliation":[{"name":"Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles W.","family":"Beatty","sequence":"additional","affiliation":[{"name":"Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Fabry","sequence":"additional","affiliation":[{"name":"Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"bibr1-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1177\/000348947908800501"},{"key":"bibr2-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1177\/096120339700600611"},{"key":"bibr3-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198404000-00014"},{"key":"bibr4-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198206000-00009"},{"key":"bibr5-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199702000-00013"},{"key":"bibr6-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.4.410"},{"key":"bibr7-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1177\/019459988309100106"},{"key":"bibr8-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240308"},{"key":"bibr9-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198406000-00006"},{"key":"bibr10-000348940010900802","first-page":"196","volume":"10","author":"McCabe BF","year":"1989","journal-title":"Am J Otol"},{"key":"bibr11-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1007\/BF02214943"},{"key":"bibr12-000348940010900802","first-page":"335","volume-title":"Second line agents in the treatment of rheumatic diseases","author":"Clements PJ","year":"1991"},{"key":"bibr13-000348940010900802","first-page":"575","volume":"4","author":"Songsiridey N","year":"1990","journal-title":"Clin Rheumatol"},{"key":"bibr14-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770316-4"},{"key":"bibr15-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371026"},{"key":"bibr16-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.2103.507"},{"key":"bibr17-000348940010900802","doi-asserted-by":"publisher","DOI":"10.1044\/jshr.2301.05"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940010900802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940010900802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:19:02Z","timestamp":1777375142000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940010900802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1177\/000348940010900802"],"URL":"https:\/\/doi.org\/10.1177\/000348940010900802","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}