{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:24:23Z","timestamp":1777422263291,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p>The cause of otosclerosis is still unknown. Recently, measles virus involvement has been implicated. The aim of this study was to analyze the presence of measles virus RNA within the otosclerotic focus and to evaluate the perilymphatic antibody pattern. Bone and perilymph specimens from 40 patients with the spontaneous form of otosclerosis and from control patients were investigated by reverse transcription polymerase chain reaction (RT-PCR), Western blot techniques, and cell culture. By the use of RT-PCR, measles virus RNA could be detected in 32 patients, but not in controls. Analysis of perilymph revealed the presence of antibodies to N, F1, and M measles virus proteins in all cases, and antibodies against H protein in 2 additional cases. In preosteoblasts cultured from otosclerotic bone chips, no measles virus RNA could be amplified. We conclude that the spontaneous form of otosclerosis is, in the vast majority of cases, a measles virus-associated disease of the otic capsule.<\/jats:p>","DOI":"10.1177\/000348940111001001","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"897-903","source":"Crossref","is-referenced-by-count":27,"title":["Persistent Measles Virus Infection and Otosclerosis"],"prefix":"10.1177","volume":"110","author":[{"given":"Wolfgang","family":"Arnold","sequence":"first","affiliation":[{"name":"Jutta Kramer"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans P.","family":"Niedermeyer","sequence":"additional","affiliation":[{"name":"Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Schuster","sequence":"additional","affiliation":[{"name":"Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang J.","family":"Neubert","sequence":"additional","affiliation":[{"name":"Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Baumann","sequence":"additional","affiliation":[{"name":"Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Sedlmeier","sequence":"additional","affiliation":[{"name":"Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,10,1]]},"reference":[{"key":"bibr1-000348940111001001","first-page":"202","volume":"41","author":"Morrison AW","year":"1967","journal-title":"Ann R Coll Surg Engl"},{"key":"bibr2-000348940111001001","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5705.345"},{"key":"bibr3-000348940111001001","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770020343022"},{"key":"bibr4-000348940111001001","first-page":"476","volume":"40","author":"Altermatt HJ","year":"1992","journal-title":"HNO"},{"key":"bibr5-000348940111001001","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100106693"},{"key":"bibr6-000348940111001001","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(87)80047-9"},{"key":"bibr7-000348940111001001","first-page":"277","volume":"44","author":"Buj\u00eda J","year":"1993","journal-title":"Acta Otorrinolaringol Esp"},{"key":"bibr8-000348940111001001","first-page":"604","volume":"19","author":"McKenna MJ","year":"1998","journal-title":"Am J Otol"},{"key":"bibr9-000348940111001001","doi-asserted-by":"publisher","DOI":"10.1126\/science.959849"},{"key":"bibr10-000348940111001001","doi-asserted-by":"crossref","unstructured":"Mills BG, Singer FR, Weiner LP, Suffin SC, Stabile E, Holst P. 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