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In the present study, serum MIF levels were analyzed in patients with Wegener's granulomatosis (WG) and relapsing polychondritis. It was shown that the serum MIF levels in these patients were significantly higher than those of normal healthy controls. In a WG patient, the MIF level showed a good correlation with clinical symptoms and C-ANCA titers. Thus, serum MIF levels will be a useful laboratory parameter for following the clinical course of WG patients and determining medical treatment. The immunopathologic roles of MIF in these diseases are discussed.<\/jats:p>","DOI":"10.1177\/000348940111001108","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"1035-1040","source":"Crossref","is-referenced-by-count":30,"title":["Serum Level of Macrophage Migration Inhibitory Factor as a Useful Parameter of Clinical Course in Patients with Wegener's Granulomatosis and Relapsing Polychondritis"],"prefix":"10.1177","volume":"110","author":[{"given":"Ryuichiro","family":"Ohwatari","sequence":"first","affiliation":[{"name":"Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Inuyama","sequence":"additional","affiliation":[{"name":"Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Ono\u00e9","sequence":"additional","affiliation":[{"name":"Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Iwabuchi","sequence":"additional","affiliation":[{"name":"Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nishihira","sequence":"additional","affiliation":[{"name":"Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"bibr1-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1126\/science.153.3731.80"},{"key":"bibr2-000348940111001108","first-page":"95","volume":"1","author":"Nishihira J","year":"1999","journal-title":"Recent Res Dev Immunol"},{"key":"bibr3-000348940111001108","first-page":"17","volume":"2","author":"Nishihira J","year":"1998","journal-title":"Int J Mol Med"},{"key":"bibr4-000348940111001108","first-page":"247","volume":"40","author":"Kitaichi N","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr5-000348940111001108","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.4049\/jimmunol.158.11.5514","volume":"158","author":"Mikulowska A","year":"1997","journal-title":"J Immunol"},{"key":"bibr6-000348940111001108","first-page":"533","volume":"58","author":"Godman GC","year":"1954","journal-title":"AMA Arch Pathol"},{"key":"bibr7-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90214-2"},{"key":"bibr8-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91147-X"},{"key":"bibr9-000348940111001108","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-1-74"},{"key":"bibr10-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331006"},{"key":"bibr11-000348940111001108","first-page":"1395","volume-title":"Clinical immunology: principles and practice","author":"Trentham DE","year":"1996"},{"key":"bibr12-000348940111001108","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1288\/00005537-197906000-00009","volume":"89","author":"Damiani JM","year":"1979","journal-title":"Laryngoscope"},{"key":"bibr13-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1997.0276"},{"key":"bibr14-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1038\/377068a0"},{"key":"bibr15-000348940111001108","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-7-199610010-00018"},{"key":"bibr16-000348940111001108","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.38.759"},{"key":"bibr17-000348940111001108","first-page":"226","volume":"14","author":"Mascher B","year":"1997","journal-title":"Exp Clin Immunogenet"},{"key":"bibr18-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.277"},{"key":"bibr19-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.055003852.x"},{"key":"bibr20-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350914"},{"key":"bibr21-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00230-6"},{"key":"bibr22-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1998.0402"},{"key":"bibr23-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115950"},{"key":"bibr24-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.6.1895"},{"key":"bibr25-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1076\/0271-3683(200002)2021-DFT109"},{"key":"bibr26-000348940111001108","doi-asserted-by":"publisher","DOI":"10.1038\/72262"}],"container-title":["Annals of Otology, Rhinology &amp; 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