{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:05:11Z","timestamp":1787799911499,"version":"build-2784847793"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p>The aim of this study was to assess the value of topically applied estrogens in patients with hereditary hemorrhagic telangiectasia. Twenty-six patients with this disorder were treated with argon plasma coagulation and randomized into 2 groups: group A, which had postoperative application of estriol ointment (n = 14), and group B, which had postoperative application of dexpanthenol ointment (n = 12). Over a period of 12 months, the frequency and intensity of bleeding, the patient's satisfaction, and the success of the treatment were evaluated with a questionnaire. Before the operation, more than 90% of the patients in both groups complained of daily episodes of epistaxis. Twelve months after treatment, the frequency and intensity of bleeding had significantly decreased in group A as compared to group B. Of the patients in group A, 93% were satisfied with the treatment. Of the patients in group B, only 42% were satisfied with the treatment. In both groups, more than 90% of the patients were willing to undergo the same treatment again. The combined treatment approach with argon plasma coagulation and topical estriol enables us to significantly prolong the hemorrhage-free interval.<\/jats:p>","DOI":"10.1177\/000348940211100306","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"222-228","source":"Crossref","is-referenced-by-count":45,"title":["Topical Estrogens Combined with Argon Plasma Coagulation in the Management of Epistaxis in Hereditary Hemorrhagic Telangiectasia"],"prefix":"10.1177","volume":"111","author":[{"given":"Wolfgang","family":"Bergler","sequence":"first","affiliation":[{"name":"Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haneen","family":"Sadick","sequence":"additional","affiliation":[{"name":"Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Riedel","sequence":"additional","affiliation":[{"name":"Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"G\u00f6tte","sequence":"additional","affiliation":[{"name":"Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"H\u00f6rmann","sequence":"additional","affiliation":[{"name":"Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"bibr1-000348940211100306","first-page":"333","volume":"12","author":"Osler W","year":"1901","journal-title":"Bull Johns Hopkins Hosp"},{"key":"bibr2-000348940211100306","first-page":"160","volume":"2","author":"Weber FP","year":"1907","journal-title":"Lancet"},{"key":"bibr3-000348940211100306","doi-asserted-by":"publisher","DOI":"10.2500\/105065897781446829"},{"key":"bibr4-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050114"},{"key":"bibr5-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00004"},{"key":"bibr6-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1062363"},{"key":"bibr7-000348940211100306","first-page":"500","volume":"64","author":"Saunders WH","year":"1960","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"bibr8-000348940211100306","first-page":"19","volume":"26","author":"Illum P","year":"1988","journal-title":"Rhinology"},{"key":"bibr9-000348940211100306","first-page":"71","volume":"2","author":"Farin G","year":"1994","journal-title":"Endosc Surg Allied Technol"},{"key":"bibr10-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1007\/s001060050293"},{"key":"bibr11-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1007\/s001060050230"},{"key":"bibr12-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1952.02930320016006"},{"key":"bibr13-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198203000-00017"},{"key":"bibr14-000348940211100306","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.34.589"},{"key":"bibr15-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91010-8"},{"key":"bibr16-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90166-9"},{"key":"bibr17-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1981.tb11614.x"},{"key":"bibr18-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780200074007"},{"key":"bibr19-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb10906.x"},{"key":"bibr20-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(94)90074-4"},{"key":"bibr21-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57482-2"},{"key":"bibr22-000348940211100306","doi-asserted-by":"publisher","DOI":"10.3109\/00016348309154209"},{"key":"bibr23-000348940211100306","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197801262980406"}],"container-title":["Annals of Otology, Rhinology &amp; 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