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In this study, messenger RNA profiles for extracellular matrix proteins \u2014 procollagen I, collagenase, elastase, fibronectin, fibromodulin, decorin, hyaluronic acid synthase 2, and hyaluronidase \u2014 were completed on 5 polyps and 4 Reinke's edema specimens. These genotypic profiles were correlated to a videostroboscopic parameter of mucosal wave stiffness, which was used as a measurement of phenotypic expression. Polyps, characterized by stiffer mucosal waves, had higher levels of gene expression, whereas stiffer mucosal wave scores for Reinke's edema were associated with lower gene activity levels. This study supports the hypothesis that there is a relationship between genotypic expression found in polyps and Reinke's edema and phenotype as defined by a loss of or a decreased mucosal wave. The study also gives clues as to the proteins responsible for the phenotype.<\/jats:p>","DOI":"10.1177\/000348940211100404","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"302-309","source":"Crossref","is-referenced-by-count":41,"title":["Genotypic and Phenotypic Expression of Vocal Fold Polyps and Reinke's Edema: A Preliminary Study"],"prefix":"10.1177","volume":"111","author":[{"given":"Susan L.","family":"Thibeault","sequence":"first","affiliation":[{"name":"Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles N.","family":"Ford","sequence":"additional","affiliation":[{"name":"Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Gray","sequence":"additional","affiliation":[{"name":"Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Li","sequence":"additional","affiliation":[{"name":"Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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