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We assessed the biologic activity of the 3 ANP receptors (ANP-A, ANP-B, ANP-C) in the rat inner ear by measuring receptor upregulation after inner ear administration of ANPs. After appropriate anesthesia, female Lewis rats were injected with ANP via the round window. The animals were sacrificed 24 hours later, and RNA was isolated for reverse transcription\u2013polymerase chain reaction (RT-PCR). Electrophoresis of RT-PCR products showed the presence of all 3 ANP receptor genes in both injected and control animals. Gene expression was significantly higher 24 hours after injection. These findings demonstrate that ANP receptors in the inner ear can be upregulated after injection of ANPs.<\/jats:p>","DOI":"10.1177\/000348940211101116","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"1040-1044","source":"Crossref","is-referenced-by-count":8,"title":["Atrial Natriuretic Peptide Receptor Upregulation in the Rat Inner Ear"],"prefix":"10.1177","volume":"111","author":[{"given":"John L.","family":"Dornhoffer","sequence":"first","affiliation":[{"name":"Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Danner","sequence":"additional","affiliation":[{"name":"Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulin","family":"Li","sequence":"additional","affiliation":[{"name":"Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"bibr1-000348940211101116","unstructured":"Arenberg IK, Marovitz W, Shambaugh GEJr. The role of the endolymphatic sac in the pathogenesis of endolymphatic hydrops in man. 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