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A large number of mast cells are present in the superficial layer of subepithelial connective tissue (SECT) of the epiglottis, arytenoid, and subglottis. Although mast cells containing both tryptase and chymase are predominant in the deep layer of the SECT, the majority of mast cells containing tryptase alone are located in both the epithelial layer and the superficial layer of the SECT. We conclude that the human laryngeal mucosa has the potential to induce type I allergic reaction.<\/jats:p>","DOI":"10.1177\/000348940511400210","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"139-143","source":"Crossref","is-referenced-by-count":10,"title":["Immunohistochemical Study on Distribution of Mast Cell Phenotypes in Human Laryngeal Mucosa: Evidence for Laryngeal Type I Allergy"],"prefix":"10.1177","volume":"114","author":[{"given":"Haruhiko","family":"Ishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemichi","family":"Iwae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsuo","family":"Amatsu","sequence":"additional","affiliation":[{"name":"Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,2,1]]},"reference":[{"key":"bibr1-000348940511400210","first-page":"249","volume-title":"Allergy and immunology \u2014 an otolaryngic approach","author":"Chadwick SJ","year":"2002"},{"key":"bibr2-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)33048-6"},{"key":"bibr3-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70038-4"},{"key":"bibr4-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050188"},{"key":"bibr5-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050142"},{"key":"bibr6-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)32820-6"},{"key":"bibr7-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1996.tb01023.x"},{"key":"bibr8-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100416"},{"key":"bibr9-000348940511400210","first-page":"303","volume-title":"Allergy","author":"Church MK","year":"2001","edition":"2"},{"key":"bibr10-000348940511400210","first-page":"607","volume-title":"Histology \u2014 a text and atlas","author":"Rhodin JAG","year":"1974"},{"key":"bibr11-000348940511400210","first-page":"497","volume-title":"Textbook of histology","author":"Boerhaave H","year":"1986","edition":"1"},{"key":"bibr12-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1992.tb00194.x"},{"key":"bibr13-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb01023.x"},{"key":"bibr14-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1159\/000234317"},{"key":"bibr15-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1989.tb02357.x"},{"key":"bibr16-000348940511400210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1999.tb04406.x"},{"key":"bibr17-000348940511400210","first-page":"7","volume":"64","author":"Okuda M","year":"1983","journal-title":"Eur J Respir Dis Suppl"},{"key":"bibr18-000348940511400210","first-page":"135","volume":"157","author":"Lidegran M","year":"1996","journal-title":"Effect of compound 48\/80 and dexamethasone: a quantitative and immunohistochemical study at the light- and electron-microscopic levels. 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