{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T12:33:01Z","timestamp":1780749181764,"version":"3.54.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We performed a prospective study to determine the cutoff value and the prognostic value of Cyfra 21\u20131, a serum tumor marker, in head and neck squamous cell carcinoma (HNSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The serum concentration of Cyfra 21\u20131 was measured in a group of 300 patients (group 1) with HNSCC, in a control group of 71 healthy subjects (group 2), and in a group of 73 patients with a nonmalignant tumor or inflammatory disease (group 3). The concentrations were compared between the various groups and subgroups; the cutoff value was calculated with a receiver operating characteristic curve. Furthermore, the serum concentrations of Cyfra 21\u20131 before treatment in the group of 300 patients were compared with the stage of the disease and with the evolution of the overall survival rate and the disease-free survival rate. Finally, to determine whether Cyfra 21\u20131 is an independent prognostic factor, we compared the concentrations, by a Cox model, with the classic prognostic factors of HNSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At the cutoff value of 1 ng\/mL, the specificity was 94% and the sensitivity was 72%. The serum concentrations of Cyfra 21\u20131 were statistically correlated with the stage of the disease. The overall survival rate and the disease-free survival rate were lower in patients with high serum concentrations, and these differences were statistically significant (p &lt;.001). The Cox model allows us to conclude that Cyfra 21\u20131 is a prognostic marker that is independent of other classic prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Cyfra 21\u20131 is an interesting tumor marker that could be proposed for the early detection of HNSCC with a cutoff value of 1 ng\/mL. Furthermore, Cyfra 21\u20131 can be considered an independent prognostic marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940511401006","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"768-776","source":"Crossref","is-referenced-by-count":21,"title":["Study of Cyfra 21\u20131, a Tumor Marker, in Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"114","author":[{"given":"Philippe","family":"C\u00e9ruse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Rabilloud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Charri\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dubreuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Disant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"bibr1-000348940511401006","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910410205"},{"key":"bibr2-000348940511401006","first-page":"4779","volume":"18","author":"Sankaranarayanan R","year":"1998","journal-title":"Anticancer Res"},{"key":"bibr3-000348940511401006","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000715)87:2<301::AID-IJC24>3.0.CO;2-Y"},{"key":"bibr4-000348940511401006","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(90)90278-2"},{"key":"bibr5-000348940511401006","doi-asserted-by":"publisher","DOI":"10.1016\/0964-1955(94)90046-9"},{"key":"bibr6-000348940511401006","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880150310"},{"key":"bibr7-000348940511401006","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90400-7"},{"key":"bibr8-000348940511401006","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01387.x"},{"key":"bibr9-000348940511401006","first-page":"61","volume":"53","author":"Pujol JL","year":"1993","journal-title":"Cancer Res"},{"key":"bibr10-000348940511401006","first-page":"707","volume":"72","author":"Stieber P","year":"1993","journal-title":"A new marker in lung cancer. 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