{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:11:37Z","timestamp":1777421497555,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We performed this study to investigate the expression profile of immune-associated genes and to probe the role of related genes in the immune pathogenesis of nasal polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Microarray analysis was used to find the expression profile of 491 immune-associated genes in nasal polyps. In validation studies, immunohistochemical staining and Western blot analysis were used to detect interleukin (IL)\u201317 and IL-17 receptor (IL-17R) in nasal polyps and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eighty-seven genes were differentially expressed in the immune-associated gene profile of nasal polyps, and 15 genes showed differential expression in both chips. In nasal polyp tissues, IL-17 was expressed mainly in the cytoplasm of plasma cells and to a lesser degree in the prickle cell layer of the epithelium and the acinus of the serous gland. In turbinates, IL-17 was also expressed in the same location, but the expression of IL-17 in nasal polyps and that in turbinates differed significantly (p &gt; .05). Both IL-17 and IL-17R displayed specific bands in nasal polyps and turbinates, but the bands of IL-17 and IL-17R in nasal polyps were stronger than those in turbinates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The differentially expressed genes in immune-associated gene chips will provide clues about, and a theoretical foundation for, the pathogenesis of nasal polyps. Furthermore, IL-17 may play an important role in the occurrence of nasal polyps by overexpression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940611500609","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"450-456","source":"Crossref","is-referenced-by-count":26,"title":["Expression Profile of Immune-Associated Genes in Nasal Polyps"],"prefix":"10.1177","volume":"115","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Dong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,6,1]]},"reference":[{"key":"bibr1-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.12.6.7539273"},{"key":"bibr2-000348940611500609","volume-title":"Nasal polyps: Relationship to infection and inflammation","author":"Stierna PLE","year":"1997"},{"key":"bibr3-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03767.x"},{"key":"bibr4-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100205"},{"key":"bibr5-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200302000-00001"},{"key":"bibr6-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)01961-5"},{"key":"bibr7-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(99)00038-3"},{"key":"bibr8-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119145"},{"key":"bibr9-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01764.x"},{"key":"bibr10-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1089\/107999003321455507"},{"key":"bibr11-000348940611500609","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.7045"},{"key":"bibr12-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00030"},{"key":"bibr13-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33362"},{"key":"bibr14-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.13.6.7576701"},{"key":"bibr15-000348940611500609","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.4049\/jimmunol.155.12.5483","volume":"155","author":"Yao Z","year":"1995","journal-title":"J Immunol"},{"key":"bibr16-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1998.0433"},{"key":"bibr17-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90070-5"},{"key":"bibr18-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.7.1233"},{"key":"bibr19-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2593"},{"key":"bibr20-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400609"},{"key":"bibr21-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.117929"},{"key":"bibr22-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200310000-00027"},{"key":"bibr23-000348940611500609","doi-asserted-by":"publisher","DOI":"10.1042\/bst0280563"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940611500609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940611500609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:17:11Z","timestamp":1777375031000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940611500609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1177\/000348940611500609"],"URL":"https:\/\/doi.org\/10.1177\/000348940611500609","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}