{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:11:40Z","timestamp":1777421500394,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This pilot study evaluated the role of cartilage-derived morphogenic proteins (CDMPs) as promoters of cartilage growth and differentiation and as a possible alternative to autologous cartilage grafts in laryngotracheal reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In phase 1, 6 New Zealand rabbits underwent subperichondrial injection of CDMP-1, CDMP-2, or CDMP-3 in the right thyroid ala and normal saline solution in the left thyroid ala as controls. In phase 2, 14 rabbits underwent anterior cricoid split and interposition of a fibrillar collagen sponge saturated with normal saline solution, CDMP-2, or CDMP-3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In both phases, saline solution failed to induce new cartilage or bone growth. Small foci of cartilage and\/or bone formation were observed within the thyroid subperichondria of those rabbits injected with CDMP-2 or CDMP-3. In phase 2, a few small foci of new cartilage and\/or bone formation were observed at the edges of the cricoid split with CDMP-2 and CDMP-3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A different carrier of CDMP, a change in dosage, or a combination of CDMPs might yield more significant neochondrification. The role of CDMPs as promoters of cartilage and differentiation could not be disqualified in this study and should be further investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940611500613","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"477-481","source":"Crossref","is-referenced-by-count":1,"title":["Laryngotracheal Stenosis Repair Using Cartilage-Derived Morphogenic Proteins: A Pilot Study"],"prefix":"10.1177","volume":"115","author":[{"given":"LenhAnh P.","family":"Tran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George H.","family":"Zalzal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,6,1]]},"reference":[{"key":"bibr1-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1177\/019459988609400213"},{"key":"bibr2-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)46918-9"},{"key":"bibr3-000348940611500613","doi-asserted-by":"crossref","unstructured":"Luyten FP. Cartilage-derived morphogenetic proteins. Key regulators in chondrocyte differentiation? Acta Orthop Scand Suppl 1995(suppl 266):51\u20134.","DOI":"10.3109\/17453679509157647"},{"key":"bibr4-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1038\/ng0396-315"},{"key":"bibr5-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.8.901"},{"key":"bibr6-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910000207"},{"key":"bibr7-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410301113"},{"key":"bibr8-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)90092-2"},{"key":"bibr9-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199203000-00004"},{"key":"bibr10-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110500609"},{"key":"bibr11-000348940611500613","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880040069012"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940611500613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940611500613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:17:12Z","timestamp":1777375032000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940611500613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1177\/000348940611500613"],"URL":"https:\/\/doi.org\/10.1177\/000348940611500613","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}