{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:12:40Z","timestamp":1777421560176,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We explored a potential association between nasal polyps (NPs) and polymorphism at loci for human leukocyte antigen (HLA) DR and HLA-DQ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Polymorphism at loci HLA-DR and HLA-DQ were examined in 30 patients with NPs and in 81 healthy subjects by use of the polymerase chain reaction-sequence specific primer method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>HLA-DR16, HLA-DQ8, and HLA-DQ9 were found to be significantly associated with NPs. HLA-DR16, HLA-DQ8, and HLA-DQ9 specificities were found at higher frequencies in patients with NPs than in control subjects (5% versus 0.62%, RR = 8.9, p = .03; 10% versus 2.47%, RR = 4.81, p = .01; and 20% versus 6.18%, RR = 4.73%, p = .001; respectively). In contrast, HLA-DQ7 was found at lower frequencies in patients with NPs than in controls (10% versus 20.37%, RR = 0.36, p = .04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We conclude that HLA-DR16, HLA-DQ8, and HLA-DQ9 represent potential susceptibility determinants and that HLA-DQ7 might confer resistance in nasal polyps.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940711600111","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"66-68","source":"Crossref","is-referenced-by-count":19,"title":["Polymorphism between Loci for Human Leukocyte Antigens DR and DQ in Patients with Nasal Polyps"],"prefix":"10.1177","volume":"116","author":[{"given":"Lijie","family":"Zhai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linghao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"bibr1-000348940711600111","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100147462"},{"key":"bibr2-000348940711600111","first-page":"87","volume":"15","author":"Tos M","year":"1977","journal-title":"Rhinology"},{"key":"bibr3-000348940711600111","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100105"},{"key":"bibr4-000348940711600111","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900415"},{"key":"bibr5-000348940711600111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02194.x"},{"key":"bibr6-000348940711600111","first-page":"183","volume":"38","author":"Liu TY","year":"2003","journal-title":"Zhonghua Er Bi Yan Hou Ke Za Zhi"},{"key":"bibr7-000348940711600111","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003000-00017"},{"key":"bibr8-000348940711600111","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91796-7"},{"key":"bibr9-000348940711600111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1974.tb00230.x"},{"key":"bibr10-000348940711600111","first-page":"395","volume":"69","author":"Leprini A","year":"1993","journal-title":"Boll Soc Ital Biol Sper"},{"key":"bibr11-000348940711600111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00709.x"},{"key":"bibr12-000348940711600111","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.9888"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940711600111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940711600111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:17:27Z","timestamp":1777375047000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940711600111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1177\/000348940711600111"],"URL":"https:\/\/doi.org\/10.1177\/000348940711600111","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}