{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:14:54Z","timestamp":1777421694478,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      Dendritic cells (DC\n                      <jats:sub>s<\/jats:sub>\n                      ) are key instigators of rejection after transplantation. Their distribution has not been systematically characterized in all locations of the larynx and its surrounding tissues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Rat larynges were stained with monoclonal antibodies identifying DCs. These cells were then enumerated by a new combination of techniques including immunofluorescence, confocal microscopy, and imaging software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The vast majority of DCs were located in the epithelium and subepithelium of the airway; the mean DC density ranged from 9 cells per square millimeter (0.2% of cells) to 645 cells per square millimeter (10.3% of cells). Their density in the epithelium was 3 to 11 times higher than that in the subepithelium. Non-airway sites (thyroid, parathyroid, muscle, fat) had mean DC densities varying from 3 cells per square millimeter (0.2%) to 57 cells per square millimeter (0.8%). No DCs were detected in cartilage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dendritic cells are concentrated in the laryngotracheal epithelium and subepithelium and represent a much smaller proportion in the other sites studied. A baseline for laryngeal DC population studies has been established, and a computerized model for consistent quantitation using confocal microscopy has been developed. This unique method will serve as a foundation for investigating DC trafficking after rat laryngeal transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940711600610","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"449-456","source":"Crossref","is-referenced-by-count":11,"title":["Quantitative Analysis of OX62-Positive Dendritic Cell Distribution in the Rat Laryngeal Complex"],"prefix":"10.1177","volume":"116","author":[{"given":"Aaron D.","family":"Friedman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"Drazba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert R.","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall","family":"Strome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"bibr1-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1996.d01-779.x"},{"key":"bibr2-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1331"},{"key":"bibr3-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199912000-00020"},{"key":"bibr4-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200109000-00029"},{"key":"bibr5-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02161.x"},{"key":"bibr6-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.001415"},{"key":"bibr7-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1159\/000235107"},{"key":"bibr8-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.6.1345"},{"key":"bibr9-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.203"},{"key":"bibr10-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199606000-00013"},{"key":"bibr11-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1007\/BF00615111"},{"key":"bibr12-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.1.307"},{"key":"bibr13-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.5.1483"},{"key":"bibr14-000348940711600610","first-page":"3337","volume":"25","author":"Demetris AJ","year":"1993","journal-title":"Transplant Proc"},{"key":"bibr15-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211101211"},{"key":"bibr16-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100701"},{"key":"bibr17-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.6.1457"},{"key":"bibr18-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(03)00048-0"},{"key":"bibr19-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000048380.84355.4A"},{"key":"bibr20-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199912270-00001"},{"key":"bibr21-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000154267.42933.5d"},{"key":"bibr22-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.19.4.2870"},{"key":"bibr23-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.6.2429"},{"key":"bibr24-000348940711600610","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-8749(03)00026-1"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940711600610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940711600610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:17:53Z","timestamp":1777375073000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940711600610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1177\/000348940711600610"],"URL":"https:\/\/doi.org\/10.1177\/000348940711600610","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}