{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:12:46Z","timestamp":1777421566817,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study was designed to evaluate the efficacy and feasibility of our intra-arterial chemotherapy protocol with a lower amount and frequency of cisplatin delivery than in RADPLAT for the treatment of resectable advanced head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifty-one patients with advanced squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx were included in this prospective study. The patients were treated with 3 courses of cisplatin (100 mg at 1 treatment, intra-arterial) and sodium thiosulfate (28 g at 1 treatment, intravenous) once every 2 weeks during concurrent radiotherapy (66 to 70 Gy, 2 Gy per fraction, daily for 5 days over 7 weeks). Nodal metastases larger than 3 cm in diameter were treated with an additional 50 mg of cisplatin. The patients with less than 50% tumor reduction after 40 Gy and 2 courses of chemotherapy were treated with surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The protocol was completed for 49 patients. All living patients had a minimum follow-up period of 2 years. Including the 3 patients with salvage surgery, local disease-free control was achieved in 39 patients (80%). For 36 patients (73.5%), disease-free primary organs were preserved at 2 years after treatment. Locoregional disease-free control for 2 years was obtained for 38 patients (77.6%), in 30 of them without salvage surgery. The patients treated with surgery had an overall survival rate similar to that of the patients with a complete response (80% and 84.6%, respectively). The patients with a partial response had a worse prognosis (40%; p = 0069).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This treatment regimen is feasible and effective for advanced resectable head and neck cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940711601007","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"754-761","source":"Crossref","is-referenced-by-count":18,"title":["Intra-Arterial Chemotherapy Less Intensive Than RADPLAT with Concurrent Radiotherapy for Resectable Advanced Head and Neck Squamous Cell Carcinoma: A Prospective Study"],"prefix":"10.1177","volume":"116","author":[{"given":"Tomokazu","family":"Yoshizaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Wakisaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Murono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Takanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ichiro","family":"Sanada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Terayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"bibr1-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<876::AID-CNCR19>3.0.CO;2-Y"},{"key":"bibr2-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.021"},{"key":"bibr3-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031317"},{"key":"bibr4-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20231"},{"key":"bibr5-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.1.26"},{"key":"bibr6-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.106"},{"key":"bibr7-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80089-3"},{"key":"bibr8-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.12.1451"},{"key":"bibr9-000348940711601007","first-page":"809","volume":"127","author":"Wilson WR","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"bibr10-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.1.44"},{"key":"bibr11-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20974"},{"key":"bibr12-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.10.2113"},{"key":"bibr13-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20556"},{"key":"bibr14-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.168"},{"key":"bibr15-000348940711601007","first-page":"935","volume":"19","author":"Kerber CW","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr16-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200210000-00006"},{"key":"bibr17-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(97)00147-5"},{"key":"bibr18-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199710)19:7<559::AID-HED1>3.0.CO;2-6"},{"key":"bibr19-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.2.142"},{"key":"bibr20-000348940711601007","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20803"}],"container-title":["Annals of Otology, Rhinology &amp; 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