{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:01:32Z","timestamp":1787018492032,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Our previous research demonstrated that vitamin A might be related to vocal fold development. The purpose of this study was to determine whether vitamin A deficiency affects prenatal laryngeal development in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two considerations were necessary in designing a study using a rat model: For embryonic survival, vitamin A is necessary through day 10 of gestation, and laryngeal formation occurs primarily after day 11. Thus, we created a rat model that developed vitamin A deficiency after embryonic day 11. Ten pregnant rats (5 vitamin A-deficient rats and 5 control rats) were studied. Embryos were collected at embryonic day 18.5 and analyzed histologically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eighteen percent of the vitamin A-deficient embryos were alive and demonstrated laryngotracheal cartilage malformation, incomplete separation of the glottis, and\/or laryngoesophageal clefts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results document the important role played by vitamin A in laryngeal development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940711601011","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"785-792","source":"Crossref","is-referenced-by-count":14,"title":["Prenatal Vitamin a Deficiency Causes Laryngeal Malformation in Rats"],"prefix":"10.1177","volume":"116","author":[{"given":"Ichiro","family":"Tateya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Tateya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca Lynn","family":"Surles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Tanumihardjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M.","family":"Bless","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"bibr1-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00186.2004"},{"key":"bibr2-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01497.x"},{"key":"bibr3-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1080\/0036554021000028077"},{"key":"bibr4-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400704"},{"key":"bibr5-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500310"},{"key":"bibr6-000348940711601011","volume":"102","author":"Henick DH","year":"1993","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"bibr7-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.16.3111"},{"key":"bibr8-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod53.6.1392"},{"key":"bibr9-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13459"},{"key":"bibr10-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9635"},{"key":"bibr11-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9926(200012)62:6<374::AID-TERA4>3.0.CO;2-5"},{"key":"bibr12-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)90027-X"},{"key":"bibr13-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.5.1186"},{"key":"bibr14-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000830303"},{"key":"bibr15-000348940711601011","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1542\/peds.1.4.462","volume":"1","author":"Warkany J","year":"1948","journal-title":"Pediatrics"},{"key":"bibr16-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000850106"},{"key":"bibr17-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000920202"},{"key":"bibr18-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a103720"},{"key":"bibr19-000348940711601011","first-page":"387","volume-title":"The retinoids","author":"Hofmann C","year":"1994","edition":"2"},{"key":"bibr20-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1006\/scel.1994.1015"},{"key":"bibr21-000348940711601011","first-page":"53","volume":"3","author":"Linney E","year":"1994","journal-title":"Adv Devel Biol"},{"key":"bibr22-000348940711601011","first-page":"189","volume-title":"Vitamin A in health and disease","author":"Kastner P","year":"1994"},{"key":"bibr23-000348940711601011","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1242\/dev.120.10.2723","volume":"120","author":"Lohnes D","year":"1994","journal-title":"Development"},{"key":"bibr24-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.10.2749"},{"key":"bibr25-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80364-5"},{"key":"bibr26-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00121-5"},{"key":"bibr27-000348940711601011","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.60.1.267"}],"container-title":["Annals of Otology, Rhinology &amp; 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