{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:09:57Z","timestamp":1792058997015,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We test the hypothesis that treatment of gastroesophageal reflux disease (GERD) can improve obstructive sleep apnea-hypopnea syndrome (OSAHS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>One hundred forty-six patients with OSAHS underwent a complete history-taking, physical examination, and laboratory testing, including questions related to GERD symptoms. Full-night attended polysomnography, 24-hour wireless pH study at the upper esophagus, snoring level evaluation, Epworth Sleepiness Scale, and quality-of-life surveys were completed for each patient. Patients who tested positive for GERD were treated with esomeprazole magnesium 40 mg once daily for 2 to 12 months. The 24-hour pH study was repeated, and those patients with elimination of GERD were reevaluated by polysomnography, snoring level evaluation, Epworth Sleepiness Scale, quality-of-life surveys, and subjective data collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Forty-one patients completed single-dose treatment with esomeprazole, but the repeat 24-hour pH study showed that 9 patients had persistent GERD. In the 29 patients who completed phase 2 with normal pH study findings, the snoring level decreased from 9.7 \u00b1 0.5 to 7.9 \u00b1 1.3 (p &lt; .0001), the Epworth Sleepiness Scale score decreased from 14.2 \u00b1 2.5 to 11.1 \u00b1 2.4 (p &lt; .0001), the apnea-hypopnea index decreased from 37.9 \u00b1 19.1 to 28.8 \u00b1 11.5 (p = .006), and the minimum saturation of oxygen increased from 84.1% \u00b1 7.8% to 86.9% \u00b1 5.0% (p = .055).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Treatment of GERD had a significant impact on the reduction of the apnea-hypopnea index, snoring, and daytime sleepiness. Elimination of GERD should be part of a comprehensive treatment plan for patients with OSAHS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940711601103","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:40:52Z","timestamp":1412347252000},"page":"805-811","source":"Crossref","is-referenced-by-count":48,"title":["Impact of Treatment of Gastroesophageal Reflux on Obstructive Sleep Apnea-Hypopnea Syndrome"],"prefix":"10.1177","volume":"116","author":[{"given":"Michael","family":"Friedman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berk","family":"Gurpinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Ching","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Schalch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninos J.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,11,1]]},"reference":[{"key":"bibr1-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1002\/ar.b.20120"},{"key":"bibr2-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.05.003"},{"key":"bibr3-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.1.41"},{"key":"bibr4-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1539"},{"key":"bibr5-000348940711601103","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-6-200203190-00020"},{"key":"bibr6-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199312000-00002"},{"key":"bibr7-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00003"},{"key":"bibr8-000348940711601103","first-page":"78","volume":"38","author":"Bortolotti M","year":"2006","journal-title":"Dig Liver Dis"},{"key":"bibr9-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.6.2101"},{"key":"bibr10-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1416-8"},{"key":"bibr11-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00012"},{"key":"bibr12-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02213.x"},{"key":"bibr13-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14612669"},{"key":"bibr14-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/12.5.475"},{"key":"bibr15-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.04.014"},{"key":"bibr16-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.2.156"},{"key":"bibr17-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1007\/BF01071906"},{"key":"bibr18-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2001.00848.x"},{"key":"bibr19-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30982-8"},{"key":"bibr20-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.3.781"},{"key":"bibr21-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.6.1748"},{"key":"bibr22-000348940711601103","first-page":"S23","volume":"14","author":"Close LG","year":"2002","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"bibr23-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.125760"},{"key":"bibr24-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200106000-00009"},{"key":"bibr25-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01756.x"},{"key":"bibr26-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.10.011"},{"key":"bibr27-000348940711601103","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.12.004"}],"container-title":["Annals of Otology, Rhinology &amp; 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