{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:45:17Z","timestamp":1791027917105,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Vitamin A plays important roles in development, growth, and regeneration. Vitamin A-storing stellate cells have been identified in several organs. The functional roles of vitamin A in the vocal folds are still unknown, although vitamin A-storing vocal fold stellate cells have been observed in the macula flava of human and rat vocal folds. The purpose of this study was to investigate the roles of vitamin A in vocal folds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Vitamin A-deficient rats were generated, and the vocal folds were examined histologically. Messenger RNA was extracted from the vocal folds and analyzed by real-time polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Immunohistochemical analysis of normal vocal folds revealed expression of retinoic acid receptor \u03b1 in vocal fold stellate cells. The cells in the macula flava of vitamin A-deficient rats showed a larger nucleus\/cytoplasm ratio than did those of vitamin A-sufficient rats, but messenger RNA expression of major extracellular matrix components in the macula flava of vitamin A-deficient rats did not present a remarkable change except for procollagen type I. Expression of hyaluronic acid, collagen types I and III, and elastin did not show a significant change in vitamin A-deficient rat vocal folds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results indicate that vitamin A is not essential to maintaining the extracellular matrix of normal adult vocal folds, although vocal fold stellate cells participate in vitamin A storage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940811700113","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:44:54Z","timestamp":1412347494000},"page":"65-73","source":"Crossref","is-referenced-by-count":9,"title":["Roles of Vitamin a and Macula Flava in Maintaining Vocal Folds"],"prefix":"10.1177","volume":"117","author":[{"given":"Tomoko","family":"Tateya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Tateya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca Lynn","family":"Surles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Tanumihardjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M.","family":"Bless","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,1,1]]},"reference":[{"key":"bibr1-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01497.x"},{"key":"bibr2-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37232-1"},{"key":"bibr3-000348940811700113","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2002.11.7.26421"},{"key":"bibr4-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2004.1470"},{"key":"bibr5-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17558"},{"key":"bibr6-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20004"},{"key":"bibr7-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1080\/0036554021000028077"},{"key":"bibr8-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400303"},{"key":"bibr9-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500310"},{"key":"bibr10-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.16.3111"},{"key":"bibr11-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)90027-X"},{"key":"bibr12-000348940811700113","first-page":"897","volume":"49","author":"Tanumihardjo SA","year":"1995","journal-title":"Eur J Clin Nutr"},{"key":"bibr13-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2003.06.001"},{"key":"bibr14-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)33704-9"},{"key":"bibr15-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500210"},{"key":"bibr16-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2184.2003.00287.x"},{"key":"bibr17-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240531024"},{"key":"bibr18-000348940811700113","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/7.5.437"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940811700113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940811700113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:18:06Z","timestamp":1777375086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940811700113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1177\/000348940811700113"],"URL":"https:\/\/doi.org\/10.1177\/000348940811700113","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}