{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:17:09Z","timestamp":1777421829155,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The roles of vitamin A in the vocal fold epithelium are not well documented, although vitamin A has been used as a conservative treatment for laryngeal leukoplakia. The purpose of this study was to analyze the roles of vitamin A in vocal fold epithelial differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Vitamin A\u2013deficient (VAD) rats were generated, and the abnormality of their vocal fold epithelium was examined by hematoxylin and eosin staining and immunohistochemical analysis for keratin 10 and transglutaminase (TGase) 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The VAD experimental rats exhibited orthokeratosis of the vocal fold epithelium. Keratin 10 and TGase 1 were up-regulated in the epithelium of the VAD rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It is suggested that vitamin A suppresses TGase 1 expression in normal vocal folds to inhibit keratinization, and that the TGase 1 up-regulation caused by vitamin A deficiency may be related to the formation of metaplasia in the laryngeal epithelium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940811700214","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T04:34:06Z","timestamp":1504154046000},"page":"153-158","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin a Deficiency Causes Metaplasia in Vocal Fold Epithelium: A Rat Study"],"prefix":"10.1177","volume":"117","author":[{"given":"Ichiro","family":"Tateya","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Kyoto Katsura Hospital, Kyoto, Japan"},{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Tateya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"},{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca Lynn","family":"Surles","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Kanehira","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry","family":"Tanumihardjo","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane M.","family":"Bless","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"bibr1-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1089\/jam.2000.13.207"},{"key":"bibr2-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/122.11.2144"},{"key":"bibr3-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00455-8"},{"key":"bibr4-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1139\/o98-005"},{"key":"bibr5-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199611\/12)18:6<560::AID-HED11>3.0.CO;2-C"},{"key":"bibr6-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2002-0114OC"},{"key":"bibr7-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90217-X"},{"key":"bibr8-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12611394"},{"key":"bibr9-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.8.1051"},{"key":"bibr10-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1080\/02713680591005940"},{"key":"bibr11-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700113"},{"key":"bibr12-000348940811700214","first-page":"549","volume":"42","author":"Nakamura T","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr13-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240531024"},{"key":"bibr14-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91435-5"},{"key":"bibr15-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254733"},{"key":"bibr16-000348940811700214","first-page":"483","volume-title":"Diseases of the larynx.","author":"Molony N","year":"2000"},{"key":"bibr17-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990915)86:6<921::AID-CNCR5>3.0.CO;2-6"},{"key":"bibr18-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600727"},{"key":"bibr19-000348940811700214","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.8.2629"}],"container-title":["Annals of Otology, Rhinology &amp; 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