{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:17:25Z","timestamp":1777421845847,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>A concurrent group A \u03b2-hemolytic Streptococcus (GABHS)\u2013influenza virus pharyngotonsillitis (PT) is generally not considered in diagnoses, even though mixed bacterial-viral infections are common in other respiratory tract infections. This report describes our experience in diagnosing a potential mixed GABHS\u2013influenza virus PT in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Acute and convalescent antistreptolysin O (ASO) and anti-DNase B titers were obtained from 12 children with acute PT and clinical presentation that suggested viral infection, and in whom both rapid influenza A virus and rapid GABHS tests were positive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The children did not receive any antimicrobial therapy, and all recovered from their acute PT within 2 to 5 days and were all asymptomatic upon their return visit 3 to 4 weeks later. GABHS was recovered from 2 of the children on their return visit. However, ASO and anti-DNase B titers were not elevated in these individuals. The ASO and anti-DNase B titers determined in the first serum samples were less than the age-adjusted normal values for all of the children. However, these titers rose by at least two-dilution (0.2 logarithm) in the convalescent sera as compared with the acute ones in 4 of the 12 children (33%). One of the 8 children who had no increase in ASO and anti-DNase B titers had an acute GABHS PT 5 months later. One-year follow-up of all of the children showed no anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This report is the first to describe a concomitant GABHS and influenza A virus PT, as evident by increased ASO and anti-DNase B titers in a third of the patients who had both of these organisms detected in their upper airways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940811700412","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:44:54Z","timestamp":1412347494000},"page":"310-312","source":"Crossref","is-referenced-by-count":4,"title":["Concurrent Influenza A and Group A Beta-Hemolytic Streptococcal Pharyngotonsillitis"],"prefix":"10.1177","volume":"117","author":[{"given":"Itzhak","family":"Brook","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan E.","family":"Gober","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"bibr1-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.3.470"},{"key":"bibr2-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1086\/341409"},{"key":"bibr3-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1007\/BF03027968"},{"key":"bibr4-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.2.363"},{"key":"bibr5-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.153.6.624"},{"key":"bibr6-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1086\/509329"},{"key":"bibr7-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1086\/422996"},{"key":"bibr8-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.7.4104-4112.2003"},{"key":"bibr9-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.12.024"},{"key":"bibr10-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1086\/431982"},{"key":"bibr11-000348940811700412","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001904149"},{"key":"bibr12-000348940811700412","doi-asserted-by":"publisher","DOI":"10.3109\/00365548909039965"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940811700412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940811700412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:18:24Z","timestamp":1777375104000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940811700412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1177\/000348940811700412"],"URL":"https:\/\/doi.org\/10.1177\/000348940811700412","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}