{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:57:36Z","timestamp":1792789056939,"version":"4.5.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The objective of the present study was to demonstrate the efficacy of the clinical application of in situ tissue engineering using a scaffolding technique for laryngeal and tracheal tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We have developed a tissue scaffold made from a Marlex mesh tube covered by collagen sponge. Based on successful animal experimental studies, in situ tissue engineering with a scaffold implant was applied to repair the larynx and trachea in 4 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In 1 patient with subglottic stenosis, the thyroid cartilage, cricoid cartilage, and cervical trachea with scarring and granulation were resected and reconstructed by use of the scaffold. In 3 patients with thyroid cancer, the trachea and cricoid cartilage with tumor invasion were resected and the scaffold was implanted into the defect. Postoperative endoscopy during the observation period of 8 to 34 months showed a well-epithelialized airway lumen without any obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our current technique of in situ tissue engineering using a scaffold shows great potential for use in the regeneration of airway defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940811700908","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:44:54Z","timestamp":1412347494000},"page":"673-678","source":"Crossref","is-referenced-by-count":139,"title":["Clinical Application of in Situ Tissue Engineering Using a Scaffolding Technique for Reconstruction of the Larynx and Trachea"],"prefix":"10.1177","volume":"117","author":[{"given":"Koichi","family":"Omori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Tada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhisa","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Nomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsuzuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kanemaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Asato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"bibr1-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70210-3"},{"key":"bibr2-000348940811700908","first-page":"613","volume":"20","author":"Caputo V","year":"1950","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"bibr3-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(90)90063-2"},{"key":"bibr4-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500609"},{"key":"bibr5-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500409"},{"key":"bibr6-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36932-6"},{"key":"bibr7-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493529"},{"key":"bibr8-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-199507000-00019"},{"key":"bibr9-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1177\/039139880002301010"},{"key":"bibr10-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300805"},{"key":"bibr11-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400603"},{"key":"bibr12-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70218-7"},{"key":"bibr13-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-200105000-00008"},{"key":"bibr14-000348940811700908","doi-asserted-by":"publisher","DOI":"10.1177\/039139880102400109"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940811700908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940811700908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:18:35Z","timestamp":1777375115000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940811700908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1177\/000348940811700908"],"URL":"https:\/\/doi.org\/10.1177\/000348940811700908","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}