{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:16:48Z","timestamp":1777421808907,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      We assess whether negative findings on computed tomography (CT), magnetic resonance imaging (MRI), and\/or\n                      <jats:sup>18<\/jats:sup>\n                      F-fluorodeoxyglucose positron emission tomography (\n                      <jats:sup>18<\/jats:sup>\n                      FDG-PET) may contribute to the decision-making process of elective neck dissection (eND) in patients with squamous cell carcinoma of the oral cavity or the oropharynx (oSCC) staged cT1-T2 cN0 cM0.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We interpreted CT, MRI, and\n                      <jats:sup>18<\/jats:sup>\n                      FDG-PET images separately, after combining the data of CT with those of\n                      <jats:sup>18<\/jats:sup>\n                      FDG-PET and the data of MRI with those of\n                      <jats:sup>18<\/jats:sup>\n                      FDG-PET. Each set of results was then compared with the histopathologic results of ipsilateral or bilateral eND in a prospective, blinded study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The histopathologic examination of 594 lymph nodes revealed 4 metastases less than 4 mm in diameter and 3 micrometastases (less than 2 mm) in 6 of 17 patients. On CT, MRI, and\n                      <jats:sup>18<\/jats:sup>\n                      FDG-PET, respectively, 5, 5, and 0 cases were true-malignant (true positives) and 4, 10, and 1 cases were false-malignant (false positives). The accuracy was not enhanced by fusing CT with\n                      <jats:sup>18<\/jats:sup>\n                      FDG-PET or MRI with\n                      <jats:sup>18<\/jats:sup>\n                      FDG-PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The detectability threshold of occult metastases appears to be below the spatial and contrast resolution of CT, MRI, and\n                      <jats:sup>18<\/jats:sup>\n                      FDG-PET. The decision for eND in patients with cT1-T2 cN0 cM0 oSCC cannot be based upon cross-sectional imaging at the resolutions currently available.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940811701111","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:44:54Z","timestamp":1412347494000},"page":"854-863","source":"Crossref","is-referenced-by-count":37,"title":["Is There a Need for Positron Emission Tomography Imaging to Stage the N0 Neck in T1-T2 Squamous Cell Carcinoma of the Oral Cavity or Oropharynx?"],"prefix":"10.1177","volume":"117","author":[{"given":"Ursula","family":"Schroeder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Dietlein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Wittekindt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Ortmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Stuetzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Vent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Jungehuelsing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Krug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,11,1]]},"reference":[{"key":"bibr1-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161338.54515.b1"},{"key":"bibr2-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.116188"},{"key":"bibr3-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880140504"},{"key":"bibr4-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890030020004"},{"key":"bibr5-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199903)21:2<124::AID-HED5>3.0.CO;2-A"},{"key":"bibr6-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0727-3"},{"key":"bibr7-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199608000-00014"},{"key":"bibr8-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000217543.40027.1d"},{"key":"bibr9-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1054\/jcms.2000.0172"},{"key":"bibr10-000348940811701111","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.4.01841326"},{"key":"bibr11-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200208000-00009"},{"key":"bibr12-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050293"},{"key":"bibr13-000348940811701111","first-page":"1136","volume":"46","author":"Ng SH","year":"2005","journal-title":"J Nucl Med"},{"key":"bibr14-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870180037007"},{"key":"bibr15-000348940811701111","first-page":"119","volume":"52","author":"Agresti AB","year":"1998","journal-title":"Am Statistician"},{"key":"bibr16-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20062"},{"key":"bibr17-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70075-X"},{"key":"bibr18-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1007\/BF02985008"},{"key":"bibr19-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10213"},{"key":"bibr20-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10057"},{"key":"bibr21-000348940811701111","first-page":"211","volume":"36","author":"Braams JW","year":"1995","journal-title":"J Nucl Med"},{"key":"bibr22-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00121-5"},{"key":"bibr23-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199802000-00014"},{"key":"bibr24-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179388"},{"key":"bibr25-000348940811701111","first-page":"1491","volume":"41","author":"Crippa F","year":"2000","journal-title":"J Nucl Med"},{"key":"bibr26-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2381041799"},{"key":"bibr27-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.120"},{"key":"bibr28-000348940811701111","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2005.05.018"}],"container-title":["Annals of Otology, Rhinology &amp; 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