{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:57:43Z","timestamp":1790859463344,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The goal of this study was to develop a surgical method for the creation of vocal fold injuries in mice, as a precursor to the use of genetically engineered mouse models in the study of vocal fold wound healing and scar formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Seven FVB strain mice were used in this study. A laryngoscope and 3 micro-instruments were designed and fabricated to facilitate endoscopic vocal fold visualization and the creation of vocal fold surgical injuries. The larynges were harvested 1 and 7 days after surgery, and the vocal fold injury sites were evaluated by routine hematoxylin and eosin staining. Additional immunohistochemical analysis of collagen type I and elastin distribution in the lamina propria was performed for an uninjured control larynx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Endoscopic visualization and vocal fold stripping resulting in thyroarytenoid muscle exposure were successful in all animals. Histologic and immunohistochemical analyses revealed a simple lamina propria structure with relatively even collagen type I and elastin distribution in the control vocal fold, obliteration of vocal fold mucosa 1 day after surgery, and complete reepithelialization by 7 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results demonstrate the feasibility of creating reproducible vocal fold injuries via an endoscopic approach in mice. The observation that the mouse lamina propria may have a relatively simple histologic structure indicates that additional characterization should be performed and caution used in translating findings between this and other model systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940911800209","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:44:54Z","timestamp":1412347494000},"page":"131-138","source":"Crossref","is-referenced-by-count":22,"title":["Surgical Method to Create Vocal Fold Injuries in Mice"],"prefix":"10.1177","volume":"118","author":[{"given":"Masaru","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M.","family":"Bless","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan V.","family":"Welham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"bibr1-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2004.12.005"},{"key":"bibr2-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000162261.49739.b7"},{"key":"bibr3-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1115\/1.1785804"},{"key":"bibr4-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200005000-00011"},{"key":"bibr5-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200306000-00010"},{"key":"bibr6-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211101004"},{"key":"bibr7-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2003.06.001"},{"key":"bibr8-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200304000-00007"},{"key":"bibr9-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2005.06.002"},{"key":"bibr10-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400303"},{"key":"bibr11-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00078-4"},{"key":"bibr12-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1038\/nbt830"},{"key":"bibr13-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(89)90029-2"},{"key":"bibr14-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1126\/science.2660260"},{"key":"bibr15-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711600810"},{"key":"bibr16-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1177\/019262339202000106"},{"key":"bibr17-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2007.12.008"},{"key":"bibr18-000348940911800209","first-page":"3","volume-title":"Vocal fold physiology: Contemporary research and clinical issues","author":"Kurita S","year":"1983"},{"key":"bibr19-000348940911800209","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500406"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940911800209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348940911800209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:18:46Z","timestamp":1777375126000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348940911800209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1177\/000348940911800209"],"URL":"https:\/\/doi.org\/10.1177\/000348940911800209","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}