{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:20:43Z","timestamp":1777422043813,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We analyzed the impact of bilaterality and headache on the health-related quality of life (HRQL) of patients with Meniere's disease (MD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case series including 86 patients with a diagnosis of definite MD according to the American Academy of Otolaryngology\u2013Head and Neck Surgery (AAO-HNS) diagnostic criteria was evaluated by the Short Form 36 (SF-36) Health Instrument and the Dizziness Handicap Inventory Short Form (DHI-S).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The scores on all scales of the SF-36 were significantly lower for bilateral MD than for unilateral cases, except for body pain. Both groups had scores worse than those of their sex- and age-matched normative population on all SF-36 scales (p = 0.017 to p = 0.0001), except for body pain in men. The DHI-S scores were also better for unilateral than for bilateral cases (p = 0.04), suggesting that the dizziness is perceived to be more disabling in bilateral MD. Migraine was significantly associated with bilateral MD (odds ratio, 3.58 [95% confidence interval, 1.25 to 10.31]; p = 0.021). Headache and score on the AAO-HNS functional scale, which evaluates the effect of vertigo attacks on daily activities, were two independent factors that explained a great part of the variability on all SF-36 scales, except for \u201crole emotional\u201d in bilateral MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with bilateral MD perceived their dizziness to be more disabling and had a worse HRQL than did patients with unilateral MD. Migraine was more frequently found in patients with bilateral involvement. Headache and score on the AAO-HNS functional scale were factors associated with the HRQL in bilateral MD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940911800603","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T05:06:10Z","timestamp":1496120770000},"page":"409-416","source":"Crossref","is-referenced-by-count":40,"title":["Impact of Bilaterality and Headache on Health-Related Quality of Life in Meniere's Disease"],"prefix":"10.1177","volume":"118","author":[{"given":"Jose A.","family":"Lopez-Escamez","sequence":"first","affiliation":[{"name":"Otology and Neurotology Group, Department of Otolaryngology, Hospital de Poniente, El Ejido, and FIBAO, Torrecardenas Hospital, Almeria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Viciana","sequence":"additional","affiliation":[{"name":"Otology and Neurotology Group, Department of Otolaryngology, Hospital de Poniente, El Ejido, and FIBAO, Torrecardenas Hospital, Almeria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Garrido-Fernandez","sequence":"additional","affiliation":[{"name":"Otology and Neurotology Group, Department of Otolaryngology, Hospital de Poniente, El Ejido, and FIBAO, Torrecardenas Hospital, Almeria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"bibr1-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890010017004"},{"key":"bibr2-000348940911800603","doi-asserted-by":"publisher","DOI":"10.3109\/01050399709074978"},{"key":"bibr3-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.11.1149"},{"key":"bibr4-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(91)90124-7"},{"key":"bibr5-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(92)90070-I"},{"key":"bibr6-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61161-7"},{"key":"bibr7-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200211000-00022"},{"key":"bibr8-000348940911800603","first-page":"170","volume":"10","author":"Stahle J","year":"1989","journal-title":"Am J Otol"},{"key":"bibr9-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110400603"},{"key":"bibr10-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200604000-00011"},{"key":"bibr11-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2003.00740.x"},{"key":"bibr12-000348940911800603","first-page":"155","volume":"126","author":"Cunha F","year":"2005","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"bibr13-000348940911800603","first-page":"67","volume":"18","author":"Kinney SE","year":"1997","journal-title":"Am J Otol"},{"key":"bibr14-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200111000-00030"},{"key":"bibr15-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"bibr16-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"bibr17-000348940911800603","first-page":"804","volume":"19","author":"Jacobson GP","year":"1998","journal-title":"Am J Otol"},{"key":"bibr18-000348940911800603","first-page":"410","volume":"111","author":"Alonso J","year":"1998","journal-title":"Med Clin (Bare)"},{"issue":"1","key":"bibr19-000348940911800603","first-page":"8","volume":"24","author":"International Headache Society.","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr20-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000036903.22461.39"},{"key":"bibr21-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1080\/14992020600753239"},{"key":"bibr22-000348940911800603","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200107000-00020"}],"container-title":["Annals of Otology, Rhinology &amp; 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