{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:19:02Z","timestamp":1777421942330,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We investigated the effect of transforming growth factor-\u03b21 (TGF-\u03b21) on the differentiation of nasal polyp\u2013derived fibroblasts (NPDFs) and on their production of collagen, and investigated the effect of peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) agonists on the effects of TGF-\u03b21.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Primary fibroblast lines were established from 5 human nasal polyp tissues. We activated the NPDFs with TGF-\u03b21 and exposed them to the PPAR\u03b3 agonists ciglitazone and 15-deoxy-A-prostaglandin J2. The expression of \u03b1-smooth muscle actin (\u03b1-SMA) and collagen was measured by reverse transcriptase\u2013polymerase chain reactions, immunocytochemical staining, and collagen assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The treatment with TGF-\u03b21 increased the expression of \u03b1-SMA and collagen, and expression was markedly attenuated by the PPAR\u03b3 agonists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PPAR\u03b3 agonists inhibit the differentiation of TGF-\u03b21\u2013activated NPDFs and their production of collagen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348940911801007","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:44:54Z","timestamp":1412347494000},"page":"721-727","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Peroxisome Proliferator\u2014Activated Receptor Gamma Agonists on Myofibroblast Differentiation and Collagen Production in Nasal Polyp\u2014Derived Fibroblasts"],"prefix":"10.1177","volume":"118","author":[{"given":"Heung-Man","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo 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