{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:29:00Z","timestamp":1777422540098,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We evaluated the safety and efficacy of amitriptyline hydrochloride in treating idiopathic chronic laryngeal irritability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective chart review identified patients treated with amitriptyline for laryngeal irritability in an academic otolaryngology practice. Subjects who had documented medication compliance and a follow-up evaluation performed within 3 months after initiation of treatment were included. Symptoms, demographic information, and response to therapy were abstracted from the records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty-six subjects were identified, comprising 48 women and 18 men. The ethnicities were black, 42%; Hispanic, 27%; white, 20%; Asian, 6%; and other or unspecified, 5%. The response to treatment was judged complete in 32% of subjects, partial in 24%, and without improvement in 36%; the remaining 8% were unable to tolerate treatment. Overall, 56.1% of subjects improved (95% confidence limit, 43.3% to 68.3%). No significant differences in response rates were seen based on gender (p = 0.484), age (p = 0.590), or race (p = 0.846). Sedation was reported by 23% of individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We found that more than 50% of subjects who received amitriptyline for chronic laryngeal irritability experienced improvement, and most subjects tolerated this treatment. No differences in efficacy were seen among racial, age, and gender subgroups. A prospective randomized trial of this therapy appears warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348941312200105","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:44:54Z","timestamp":1412347494000},"page":"20-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Amitriptyline for Symptomatic Treatment of Idiopathic Chronic Laryngeal Irritability"],"prefix":"10.1177","volume":"122","author":[{"given":"Daniel J.","family":"Stein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Pieter","family":"Noordzij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"bibr1-000348941312200105","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00559.x"},{"key":"bibr2-000348941312200105","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2004.01.007"},{"key":"bibr3-000348941312200105","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(99)80049-6"},{"key":"bibr4-000348941312200105","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2001.24823"},{"key":"bibr5-000348941312200105","first-page":"7","volume":"2","author":"Koufman J","year":"2008","journal-title":"The Visible Voice"},{"key":"bibr6-000348941312200105","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800402"},{"key":"bibr7-000348941312200105","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000244377.60334.e3"},{"key":"bibr8-000348941312200105","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.003"},{"key":"bibr9-000348941312200105","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400401"},{"key":"bibr10-000348941312200105","first-page":"11","volume":"62","author":"Tune LE","year":"2001","journal-title":"J Clin Psychiatry"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348941312200105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348941312200105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:20:33Z","timestamp":1777375233000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348941312200105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1177\/000348941312200105"],"URL":"https:\/\/doi.org\/10.1177\/000348941312200105","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}