{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:01:36Z","timestamp":1790499696148,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Otol Rhinol Laryngol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The resolution of inflammation is an active process controlled by several anti-inflammatory and pro-resolution mediators. Lipoxin A4, an endogenous lipid mediator, is a potential pro-resolution mediator that could attenuate inflammation. This study was conducted to elucidate the role of lipoxin A4 in upper airway inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Nasal secretions were collected from patients with chronic rhinosinusitis with nasal polyposis, patients with allergic rhinitis, and control subjects. The concentration of lipoxin A4 was measured by enzyme-linked immunosorbent assay. Nasal tissues were obtained from nasal polyps and inferior turbinates during endonasal surgery. The mRNA expressions of lipoxygenases (LOXs), lipoxin receptor (formyl peptide receptor-like 1; FPRL-1), and cysteinyl leukotriene type 1 receptor (CysLT1R) in nasal tissues were examined by reverse-transcription polymerase chain reaction. Tissue localization of FPRL-1 was determined by immunohistochemical staining. The in vitro effect of lipoxin A4 on airway epithelial cells was also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A significant concentration of lipoxin A4 was found in nasal secretions, and the concentration was increased in patients with allergic rhinitis. The mRNA expressions of 5-LOX, 15-LOX-1, FPRL-1, and CysLT1R were significantly greater in nasal polyps than in inferior turbinates. FPRL-1 was localized in nasal epithelial cells. Lipoxin A4 inhibited tumor necrosis factor \u03b1-induced interleukin 8 release from airway epithelial cells via its receptor FPRL-1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results indicate that lipoxin A4 may play a role in the resolution of upper airway inflammation. A low concentration of lipoxin A4 may be involved in chronic inflammation of the upper airways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/000348941312201104","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T14:44:54Z","timestamp":1412347494000},"page":"683-689","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Pro-Resolution Mediator Lipoxin A4 and its Receptor in Upper Airway Inflammation"],"prefix":"10.1177","volume":"122","author":[{"given":"Shino","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Seno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Kouzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"bibr1-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00005807"},{"key":"bibr2-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00386.x"},{"key":"bibr3-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1038\/ni1056"},{"key":"bibr4-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200410-1413OC"},{"key":"bibr5-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-061OC"},{"key":"bibr6-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8653com"},{"key":"bibr7-000348941312201104","doi-asserted-by":"publisher","DOI":"10.3132\/pcrj.2008.00029"},{"key":"bibr8-000348941312201104","volume-title":"Global strategy for asthma management and prevention","author":"Global Initiative for Asthma (GINA), National Heart, Lung, and Blood Institute","year":"2006"},{"key":"bibr9-000348941312201104","volume-title":"Practical guideline for the management of allergic rhinitis in Japan","author":"Committee of the Practical Guideline for the Management of Allergic Rhinitis","year":"2009"},{"key":"bibr10-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.02.029"},{"key":"bibr11-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2010.05.002"},{"key":"bibr12-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2008.12.003"},{"key":"bibr13-000348941312201104","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6856"},{"key":"bibr14-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203522200"},{"key":"bibr15-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2005.10.004"},{"key":"bibr16-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2007.02.016"},{"key":"bibr17-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2007.186"},{"key":"bibr18-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202296999"},{"key":"bibr19-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.159046"},{"key":"bibr20-000348941312201104","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-008-7147-1"}],"container-title":["Annals of Otology, Rhinology &amp; Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348941312201104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000348941312201104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:20:38Z","timestamp":1777375238000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000348941312201104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1177\/000348941312201104"],"URL":"https:\/\/doi.org\/10.1177\/000348941312201104","relation":{},"ISSN":["0003-4894","1943-572X"],"issn-type":[{"value":"0003-4894","type":"print"},{"value":"1943-572X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}